Clinical Characteristics and Risk Stratification in Symptomatic and Asymptomatic Patients with Brugada Syndrome: Multicenter Study in Japan
| العنوان: | Clinical Characteristics and Risk Stratification in Symptomatic and Asymptomatic Patients with Brugada Syndrome: Multicenter Study in Japan |
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| المؤلفون: | Kazutaka Aonuma, Masahiko Takagi, Masayasu Hiraoka, Yasuhiro Yokoyama, Naohiko Aihara |
| المصدر: | Journal of Cardiovascular Electrophysiology. 18:1244-1251 |
| بيانات النشر: | Wiley, 2007. |
| سنة النشر: | 2007 |
| مصطلحات موضوعية: | Male, medicine.medical_specialty, Comorbidity, Risk Assessment, Sudden death, Asymptomatic, QRS complex, Japan, Risk Factors, Physiology (medical), Internal medicine, medicine, Humans, cardiovascular diseases, Brugada Syndrome, Brugada syndrome, medicine.diagnostic_test, business.industry, Incidence, Incidence (epidemiology), Atrial fibrillation, Middle Aged, medicine.disease, Survival Analysis, Survival Rate, Death, Sudden, Cardiac, Ventricular Fibrillation, Ventricular fibrillation, Cardiology, Female, medicine.symptom, Cardiology and Cardiovascular Medicine, business, Electrocardiography |
| الوصف: | Risk Stratification in Brugada Syndrome. Background: Neither the clinical characteristics nor risk stratification in Brugada syndrome have been clearly determined. We compared the clinical and ECG characteristics of symptomatic and asymptomatic patients with Brugada syndrome to identify new markers for high-risk patients. Methods: A total of 188 consecutive individuals with Brugada syndrome (mean age 53 ± 14 years, 178 males) were enrolled in the Japan Idiopathic Ventricular Fibrillation Study (J-IVFS). Clinical and ECG characteristics were evaluated in three groups of patients: Ventricular fibrillation (VF) group: patients with documented VF (N = 33); Syncope (Sy) group: patients with syncope without documented VF (N = 57); and asymptomatic (As) group: subjects without symptoms (N = 98). Their prognostic parameters were evaluated over a 3-year follow-up period. Results: (1) Clinical characteristics: incidence of past history of atrial fibrillation (AF) was significantly higher in the VF and Sy groups than in the AS group (P = 0.04). (2) On 12-lead ECG, r-J interval in lead V2 and QRS duration in lead V6 were longest in the VF group (P = 0.001, 0.002, respectively). (3) Clinical follow-up: during a mean follow-up period of 37 ± 16 months, incidences of cardiac events (sudden death and/or VF) were higher in the symptomatic (VF/Sy) groups than in the As group (P < 0.0001). The r-J interval in lead V2 ≥ 90 ms and QRS duration in lead V6 ≥ 90 ms were found to be possible predictors of recurrence of cardiac events in symptomatic patients. Conclusions: Prolonged QRS duration in precordial leads was prominent in symptomatic patients. This ECG marker may be useful for distinguishing high- from low-risk patients with Brugada syndrome. (J |
| تدمد: | 1540-8167 1045-3873 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9dde8d8c4a94b206c86ff3d4d50311a3Test https://doi.org/10.1111/j.1540-8167.2007.00971.xTest |
| حقوق: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....9dde8d8c4a94b206c86ff3d4d50311a3 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15408167 10453873 |
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