The benefit of a supplement with the antioxidant melatonin on redox status and muscle damage in resistance-trained athletes
| العنوان: | The benefit of a supplement with the antioxidant melatonin on redox status and muscle damage in resistance-trained athletes |
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| المؤلفون: | Javier Ocaña-Wilhelmi, Eduardo Guerra-Hernández, Ramy K. A. Sayed, Marisol Fernández-Ortiz, Tomás de Haro, Germaine Escames, Carlos de Teresa-Galván, Darío Acuña-Castroviejo, Iryna Rusanova, Roberto Carlos Leonardo-Mendonça |
| المصدر: | Applied Physiology, Nutrition, and Metabolism. 42:700-707 |
| بيانات النشر: | Canadian Science Publishing, 2017. |
| سنة النشر: | 2017 |
| مصطلحات موضوعية: | Blood Glucose, Male, Erythrocytes, Antioxidant, Physiology, Endocrinology, Diabetes and Metabolism, medicine.medical_treatment, medicine.disease_cause, Antioxidants, Lipid peroxidation, chemistry.chemical_compound, 0302 clinical medicine, Creatine Kinase, Melatonin, chemistry.chemical_classification, Nutrition and Dietetics, Glutathione Disulfide, Glutathione peroxidase, Alanine Transaminase, General Medicine, Glutathione, Cholesterol, Oxidation-Reduction, medicine.drug, medicine.medical_specialty, Young Adult, 03 medical and health sciences, Double-Blind Method, Physiology (medical), Internal medicine, medicine, Humans, Aspartate Aminotransferases, Circadian rhythm, Muscle, Skeletal, Triglycerides, Glutathione Peroxidase, L-Lactate Dehydrogenase, Resistance Training, 030229 sport sciences, Diet, Oxidative Stress, Endocrinology, chemistry, Advanced oxidation protein products, Athletes, Dietary Supplements, Lipid Peroxidation, 030217 neurology & neurosurgery, Oxidative stress |
| الوصف: | Previous data showed that the administration of high doses of melatonin improved the circadian system in athletes. Here, we investigated in the same experimental paradigm whether the antioxidant properties of melatonin has also beneficial effects against exercise-induced oxidative stress and muscle damage in athletes. Twenty-four athletes were treated with 100 mg·day−1 of melatonin or placebo 30 min before bedtime during 4 weeks in a randomized double-blind scheme. Exercise intensity was higher during the study that before starting it. Blood samples were collected before and after treatment, and plasma was used for oxygen radical absorption capacity (ORAC), lipid peroxidation (LPO), nitrite plus nitrate (NOx), and advanced oxidation protein products (AOPP) determinations. Glutathione (GSH), glutathione disulphide (GSSG) levels, and glutathione peroxidase (GPx) and reductase (GRd) activities, were measured in erythrocytes. Melatonin intake increased ORAC, reduced LPO and NOx levels, and prevented the increase of AOPP, compared to placebo group. Melatonin was also more efficient than placebo in reducing GSSG·GSH−1 and GPx·GRd−1 ratios. Melatonin, but not placebo, reduced creatine kinase, lactate dehydrogenase, creatinine, and total cholesterol levels. Overall, the data reflect a beneficial effect of melatonin treatment in resistance-training athletes, preventing extra- and intracellular oxidative stress induced by exercise, and yielding further skeletal muscle protection against exercise-induced oxidative damage. |
| تدمد: | 1715-5320 1715-5312 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9dbf0a31c41ff0c055958866d594c268Test https://doi.org/10.1139/apnm-2016-0677Test |
| حقوق: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....9dbf0a31c41ff0c055958866d594c268 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 17155320 17155312 |
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