التفاصيل البيبلوغرافية
| العنوان: |
Discordant association of islet autoantibodies with high-risk HLA genes in Chinese type 1 diabetes |
| المؤلفون: |
Xinyu Xu, Zhiguang Zhou, Yong Gu, Mei Zhang, Chunyan Xing, John C. Hutton, George S. Eisenbarth, Hui Yang, Tao Yang, Heng Chen, Liping Yu, Yu Liu, Zhixiao Wang |
| المصدر: |
Diabetes/Metabolism Research and Reviews. 27:899-905 |
| بيانات النشر: |
Wiley, 2011. |
| سنة النشر: |
2011 |
| مصطلحات موضوعية: |
Adult, Male, musculoskeletal diseases, Adolescent, Endocrinology, Diabetes and Metabolism, Single-nucleotide polymorphism, Zinc Transporter 8, Human leukocyte antigen, Body Mass Index, Islets of Langerhans, Endocrinology, Asian People, immune system diseases, Diabetes mellitus, Internal Medicine, medicine, Humans, Receptor-Like Protein Tyrosine Phosphatases, Class 8, Child, skin and connective tissue diseases, Cation Transport Proteins, Aged, Autoantibodies, Type 1 diabetes, geography, Polymorphism, Genetic, geography.geographical_feature_category, HLA-A Antigens, biology, Glutamate Decarboxylase, business.industry, Autoantibody, Infant, Middle Aged, medicine.disease, Islet, Cross-Sectional Studies, Diabetes Mellitus, Type 1, Case-Control Studies, Child, Preschool, Immunology, biology.protein, Female, Antibody, business, HLA-DRB1 Chains |
| الوصف: |
Background To reveal the aetiology of diabetes, the relationships between the islet autoantibodies, human leukocyte antigen (HLA)-A and DRB1 genotypes in the Chinese patients with type l diabetes (T1D) were investigated in our study. Methods In the cross-sectional and case-control study, peripheral blood samples were collected from 600 T1D patients and 102 healthy controls. The genetic polymorphisms of HLA-A and DRB1 are examined with polymerase chain reaction-sequence oligonucleotide probe method. The zinc transporter 8 antibody (ZnT8A), glutamic acid decarboxylase antibody (GADA) and protein-tyrosine-phosphatase-2 autoantibody (IA2A) were detected by radioligand assay. Results The A*2402, DRB1*0301, DRB1*0405 and DRB1*0901 alleles, and A*1101-DRB1*0901, A*2402-DRB1*0405 and A*2402-DRB1*0901 haplotypes were associated with T1D (all p < 0.05). The positive rates of ZnT8A in patients carried DRB1*0901, IA2A in patients carried DRB1*0405 and A*1101-DRB1*0901 and GADA in patients carried DRB1*0901 and A*2402-DRB1*0901 were significantly higher than those not carried (p < 0.05). HLA-DRB1*0901 was the independent risk factor of positive antibody in T1D patients. In addition, higher body mass index is also related with the loss of islet function besides high-risk HLA gene and islet autoantibody (p < 0.05). Conclusions The discordant association of autoantibodies with high-risk HLA gene may indicate the different immunology mechanisms of those autoantibodies. And metabolic burden resulting from overweight may accelerate apoptosis of beta cells. Copyright © 2011 John Wiley & Sons, Ltd. |
| تدمد: |
1520-7552 |
| الوصول الحر: |
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d856aecd0985d599ebc007197fd8c14Test
https://doi.org/10.1002/dmrr.1270Test |
| حقوق: |
CLOSED |
| رقم الانضمام: |
edsair.doi.dedup.....9d856aecd0985d599ebc007197fd8c14 |
| قاعدة البيانات: |
OpenAIRE |
