Changes in the Incidence of Lower Extremity Amputations in Individuals With and Without Diabetes in England Between 2004 and 2008
| العنوان: | Changes in the Incidence of Lower Extremity Amputations in Individuals With and Without Diabetes in England Between 2004 and 2008 |
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| المؤلفون: | Azeem Majeed, Eszter P. Vamos, Jonathan Valabhji, Alex Bottle, Michael Edmonds, Christopher Millett |
| المصدر: | Diabetes Care |
| بيانات النشر: | American Diabetes Association, 2010. |
| سنة النشر: | 2010 |
| مصطلحات موضوعية: | Male, Pediatrics, NETHERLANDS, Endocrinology, Diabetes and Metabolism, medicine.medical_treatment, DISEASE, 0302 clinical medicine, Epidemiology, 030212 general & internal medicine, Amputation, POPULATION, Original Research, education.field_of_study, Incidence, Incidence (epidemiology), 11 Medical And Health Sciences, Middle Aged, Diabetic Foot, 3. Good health, Lower Extremity, symbols, Female, BURDEN, Life Sciences & Biomedicine, Adult, medicine.medical_specialty, ENDOCRINOLOGY & METABOLISM, Adolescent, Population, 030209 endocrinology & metabolism, Amputation, Surgical, Young Adult, 03 medical and health sciences, symbols.namesake, PEOPLE, Diabetes mellitus, Internal Medicine, medicine, Humans, RATES, Poisson regression, Epidemiology/Health Services Research, education, Aged, Advanced and Specialized Nursing, Science & Technology, business.industry, medicine.disease, TRENDS, Diabetic foot, Surgery, REDUCTION, Diabetes Mellitus, Type 1, Diabetes Mellitus, Type 2, Relative risk, FOOT CARE, business |
| الوصف: | OBJECTIVE To describe recent trends in the incidence of nontraumatic amputations among individuals with and without diabetes and estimate the relative risk of amputations among individuals with diabetes in England. RESEARCH DESIGN AND METHODS We identified all patients aged >16 years who underwent any nontraumatic amputation in England between 2004 and 2008 using national hospital activity data from all National Health Service hospitals. Age- and sex-specific incidence rates were calculated using the total diabetes population in England every year. To test for time trend, we fitted Poisson regression models. RESULTS The absolute number of diabetes-related amputations increased by 14.7%, and the incidence decreased by 9.1%, from 27.5 to 25.0 per 10,000 people with diabetes, during the study period (P > 0.2 for both). The incidence of minor and major amputations did not significantly change (15.7–14.9 and 11.8–10.2 per 10,000 people with diabetes; P = 0.66 and P = 0.29, respectively). Poisson regression analysis showed no statistically significant change in diabetes-related amputation incidence over time (0.98 decrease per year [95% CI 0.93–1.02]; P = 0.12). Nondiabetes-related amputation incidence decreased from 13.6 to 11.9 per 100,000 people without diabetes (0.97 decrease by year [0.93–1.00]; P = 0.059). The relative risk of an individual with diabetes undergoing a lower extremity amputation was 20.3 in 2004 and 21.2 in 2008, compared with that of individuals without diabetes. CONCLUSIONS This national study suggests that the overall population burden of amputations increased in people with diabetes at a time when the number and incidence of amputations decreased in the aging nondiabetic population. |
| تدمد: | 1935-5548 0149-5992 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c8c45b05655ed6eed48ccc0c9c27116Test https://doi.org/10.2337/dc10-0989Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....9c8c45b05655ed6eed48ccc0c9c27116 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 19355548 01495992 |
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