The Role of Maternally Acquired Antibody in Providing Protective Immunity Against Nontyphoidal Salmonella in Urban Vietnamese Infants: A Birth Cohort Study
| العنوان: | The Role of Maternally Acquired Antibody in Providing Protective Immunity Against Nontyphoidal Salmonella in Urban Vietnamese Infants: A Birth Cohort Study |
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| المؤلفون: | Tran Do Hoang Nhu, Ha Thanh Tuyen, Nguyen Trong Hieu, Tran Thi Hong Chau, Cameron P. Simmons, Guy E. Thwaites, Trinh Van Tan, Lu Lan Vi, Ruklanthi de Alwis, Nguyen Van Vinh Chau, Vu Thuy Duong, Le Thi Phuong Tu, Stephen Baker, Tran Vu Thieu Nga, Nguyen Thi Van Thuy, Corinne N. Thompson, Trang Nguyen Hoang Thu, Nhi Le Thi Quynh, Pham Van Minh, Katherine L. Anders |
| المساهمون: | Baker, Stephen [0000-0003-1308-5755], Apollo - University of Cambridge Repository |
| المصدر: | The Journal of Infectious Diseases |
| بيانات النشر: | Oxford University Press (OUP), 2018. |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | 0301 basic medicine, Serotype, Lipopolysaccharides, Male, Salmonella typhimurium, Salmonella, medicine.disease_cause, Cohort Studies, 0302 clinical medicine, Risk Factors, Seroepidemiologic Studies, Immunology and Allergy, Medicine, 030212 general & internal medicine, biology, O Antigens, infant antibodies, respiratory system, Antibodies, Bacterial, 3. Good health, Infectious Diseases, transplacentally acquired immunity, Vietnam, Salmonella enterica, Salmonella Infections, Female, maternal immunization, Antibody, seroepidemiology, circulatory and respiratory physiology, NTS, Adult, Salmonella enteritidis, Serogroup, 03 medical and health sciences, Major Articles and Brief Reports, Immunity, Nontyphoidal Salmonella, Humans, Seroconversion, Bacteria, business.industry, Infant, Newborn, Infant, biology.organism_classification, 030104 developmental biology, maternal antibodies, Immunization, nervous system, seroincidence, Immunology, Multivariate Analysis, biology.protein, business, Immunity, Maternally-Acquired |
| الوصف: | We found a high transfer ratio of anti-nontyphoidal Salmonella (NTS) antibodies from mothers to infants. Furthermore, despite a high seroincidence of NTS in infants, maternally acquired antibodies provided protection from seroconversion. Therefore, we propose prenatal immunization against NTS as a possible strategy for protecting infants from NTS disease. Background Nontyphoidal Salmonella (NTS) organisms are a major cause of gastroenteritis and bacteremia, but little is known about maternally acquired immunity and natural exposure in infant populations residing in areas where NTS disease is highly endemic. Methods We recruited 503 pregnant mothers and their infants (following delivery) from urban areas in Vietnam and followed infants until they were 1 year old. Exposure to the dominant NTS serovars, Salmonella enterica serovars Typhimurium and Enteritidis, were assessed using lipopolysaccharide (LPS) O antigen–specific antibodies. Antibody dynamics, the role of maternally acquired antibodies, and NTS seroincidence rates were modeled using multivariate linear risk factor models and generalized additive mixed-effect models. Results Transplacental transfer of NTS LPS–specific maternal antibodies to infants was highly efficient. Waning of transplacentally acquired NTS LPS–specific antibodies at 4 months of age left infants susceptible to Salmonella organisms, after which they began to seroconvert. High seroincidences of S. Typhimurium and S. Enteritidis LPS were observed, and infants born with higher anti-LPS titers had greater plasma bactericidal activity and longer protection from seroconversion. Conclusions Although Vietnamese infants have extensive exposure to NTS, maternally acquired antibodies appear to play a protective role against NTS infections during early infancy. These findings suggest that prenatal immunization may be an appropriate strategy to protect vulnerable infants from NTS disease. |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 0022-1899 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9befd8ebcb55f42ed94263dfc08a0b75Test https://researchonline.lshtm.ac.uk/id/eprint/4649720/1/The_Role_of_Maternally_Acquired_Antibody.pdfTest |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....9befd8ebcb55f42ed94263dfc08a0b75 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 00221899 |
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