Prevalence of Thyroid Autoimmunity in Sporadic Idiopathic Hypoparathyroidism in Comparison to Type 1 Diabetes and Premature Ovarian Failure
| العنوان: | Prevalence of Thyroid Autoimmunity in Sporadic Idiopathic Hypoparathyroidism in Comparison to Type 1 Diabetes and Premature Ovarian Failure |
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| المؤلفون: | Satveer Singh, Deepti Goswami, Nandita Gupta, Ravinder Goswami, Debarti Ray, Raman K. Marwaha, Neeraj Tomar |
| المصدر: | The Journal of Clinical Endocrinology & Metabolism. 91:4256-4259 |
| بيانات النشر: | The Endocrine Society, 2006. |
| سنة النشر: | 2006 |
| مصطلحات موضوعية: | Adult, Male, endocrine system, medicine.medical_specialty, Adolescent, endocrine system diseases, Hypoparathyroidism, Endocrinology, Diabetes and Metabolism, Graves' disease, Clinical Biochemistry, Comorbidity, Hashimoto Disease, Primary Ovarian Insufficiency, Thyroid Function Tests, Autoantigens, Iodide Peroxidase, Biochemistry, Thyroid function tests, Thyroiditis, Endocrinology, Thyroid peroxidase, Iron-Binding Proteins, Internal medicine, Prevalence, Humans, Medicine, Autoantibodies, Sex Characteristics, medicine.diagnostic_test, biology, business.industry, Biochemistry (medical), Thyroid, Thyroiditis, Autoimmune, Middle Aged, medicine.disease, Premature ovarian failure, Diabetes Mellitus, Type 1, medicine.anatomical_structure, Case-Control Studies, biology.protein, Female, business |
| الوصف: | Thyroid autoimmunity is the most common coexistent endocrinopathy in type 1 diabetes (T1D), Addison's disease, and premature ovarian failure (POF). Although the role of autoimmunity is being investigated in patients with sporadic idiopathic hypoparathyroidism (SIH), there is little information on coexistent thyroid autoimmunity.Our objective was to assess the prevalence of thyroid peroxidase autoantibodies (TPOAb) and thyroid dysfunction in patients with SIH and its comparison with that in T1D, POF, and Hashimoto's thyroiditis (HT) and age- and sex-matched healthy controls (for SIH).We conducted a case control study in a tertiary care setting.Subjects were consecutive patients with SIH (n = 87), T1D (n = 100), POF (n = 58), and HT (n = 47) and healthy controls (100 females and 64 males). Serum free T3, free T4, TSH, and TPOAb (normalor = 34 IU/ml) were measured by electrochemiluminescence assay. Subjects with 1) serum TSH at least 5 microU/ml along with TPOAb more than 34 IU/ml; 2) TSH at least 10 microU/ml but normal TPOAb titers; or 3) Graves' disease were considered to have thyroid dysfunction.TPOAb positivity (34 IU/ml) in females was 14.6% in SIH, 24.1% in POF, and 42.1% in T1D compared with 76.6% in HT and 9% in healthy controls. The frequencies of TPOAb positivity and thyroid dysfunction in patients with SIH were comparable to those in control and POF groups, but significantly less than in T1D and HT groups.The frequencies of TPOAb and thyroid dysfunction were not significantly higher in patients with SIH than in healthy controls, unlike in patients with T1D and POF. |
| تدمد: | 1945-7197 0021-972X |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9bc6526163b109d814bb69276b2b8d20Test https://doi.org/10.1210/jc.2006-1005Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....9bc6526163b109d814bb69276b2b8d20 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 19457197 0021972X |
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