Plasma concentrations of VCAM-1 and ICAM-1 are elevated in patients with Type 1 diabetes mellitus with microalbuminuria and overt nephropathy
| العنوان: | Plasma concentrations of VCAM-1 and ICAM-1 are elevated in patients with Type 1 diabetes mellitus with microalbuminuria and overt nephropathy |
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| المؤلفون: | Hans-Henrik Parving, Peter Karl Jacobsen, Kasper Rossing, Jan Skov Jensen, Peter Clausen, Bo Feldt-Rasmussen |
| المصدر: | Diabetic Medicine. 17:644-649 |
| بيانات النشر: | Wiley, 2000. |
| سنة النشر: | 2000 |
| مصطلحات موضوعية: | Adult, Male, medicine.medical_specialty, Endocrinology, Diabetes and Metabolism, Vascular Cell Adhesion Molecule-1, Nephropathy, Diabetic nephropathy, chemistry.chemical_compound, Endocrinology, Risk Factors, Internal medicine, Internal Medicine, medicine, Albuminuria, Humans, Diabetic Nephropathies, VCAM-1, Glycated Hemoglobin, Type 1 diabetes, Proteinuria, business.industry, Middle Aged, Intercellular Adhesion Molecule-1, medicine.disease, Intercellular adhesion molecule, Cross-Sectional Studies, Diabetes Mellitus, Type 1, Elevated serum creatinine, Solubility, chemistry, Cardiovascular Diseases, Creatinine, Female, Microalbuminuria, medicine.symptom, E-Selectin, business |
| الوصف: | SUMMARY Aims Elevated urinary albumin excretion is associated with macrovascular atherosclerotic complications in Type 1 diabetes mellitus. Adhesion molecules mediate leucocyte adhesion to the endothelium early in the atherosclerotic process. The present study tests the hypothesis that microalbuminuria and diabetic nephropathy are associated with elevated plasma concentrations of soluble vascular adhesion molecule (sVCAM)-1, soluble intercellular adhesion molecule (sICAM)-1, and soluble E-selectin (sE-selectin) aiming to illustrate factors of potential pathogenetic relevance for the excess cardiovascular disease in diabetic patients with renal complications. Methods Soluble adhesion molecule concentrations were measured by enzyme-linked immunosorbent assays (ELISA) in healthy controls (n = 16) and in 59 Type 1 diabetic patients: group 1 – patients with normoalbuminuria (n = 16); group 2 – patients with microalbuminuria (n = 15); group 3 – patients with macroalbuminuria and normal serum creatinine (n = 15), group 4 – patients with macroalbuminuria and moderately elevated serum creatinine (n = 13). Results Plasma concentrations of sVCAM-1 and sICAM-1 were similar in healthy controls and normoalbuminuric Type 1 diabetic patients, but the concentrations were increased by the presence of microalbuminuria and overt nephropathy (P |
| تدمد: | 1464-5491 0742-3071 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b5381c8ccf48f5d68497674ef5fc70bTest https://doi.org/10.1046/j.1464-5491.2000.00347.xTest |
| حقوق: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....9b5381c8ccf48f5d68497674ef5fc70b |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14645491 07423071 |
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