Are serum levels of ADAMTS5, TAS and TOS at 24–28 gestational weeks associated with adverse perinatal outcomes in gestational diabetic women?
| العنوان: | Are serum levels of ADAMTS5, TAS and TOS at 24–28 gestational weeks associated with adverse perinatal outcomes in gestational diabetic women? |
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| المؤلفون: | Basak Gumus Guler, Ali Turhan Caglar, Ozcan Erel, Dilek Uygur, Nuri Danisman, Sibel Ozler, Efser Oztas, Merve Ergin |
| المساهمون: | İstinye Üniversitesi, Sağlık Bilimleri Fakültesi, Hemşirelik Bölümü, Gumus Guler, Basak |
| المصدر: | Journal of Obstetrics and Gynaecology. 40:619-625 |
| بيانات النشر: | Informa UK Limited, 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | Adult, medicine.medical_specialty, animal structures, endocrine system diseases, Total Oxidant Status, Gestational Age, Antioxidants, 03 medical and health sciences, 0302 clinical medicine, Pregnancy, Internal medicine, Gestational Weeks, Disintegrin, Humans, Medicine, Prospective Studies, Gestational Diabetes, Metalloproteinase, Thrombospondin, A Disintegrin And Metalloproteinase With Thrombospondin Motifs 5, 030219 obstetrics & reproductive medicine, biology, business.industry, Pregnancy Outcome, Oxidative Stress Index, Obstetrics and Gynecology, medicine.disease, Gestational diabetes, Diabetes, Gestational, Oxidative Stress, Antioxidant capacity, Endocrinology, ROC Curve, Case-Control Studies, 030220 oncology & carcinogenesis, biology.protein, Gestation, Female, ADAMTS5 Protein, Insulin Resistance, Total Antioxidant Status, business |
| الوصف: | We aimed to determine the role of placental A Disintegrin and Metalloproteinase with thrombospondin motifs 5 (ADAMTS5), and maternal serum ADAMTS5, total antioxidant status (TAS), total oxidant status (TOS) and oxidative stress index (OSI) levels at 24-28th gestational weeks in GDM. This study included 57 patients, who had been diagnosed as having GDM at their 24-28th gestational week, and 29 controls. The maternal blood samples were collected at the 24-28th gestational week and ADAMTS5 was studied with the enzyme-linked immunosorbent assay (ELISA) method, whereas an automated colorimetric method was used to study TAS, TOS, and OSI. The level of ADAMTS5 in maternal serum of patients with GDM were significantly lower than the controls (p = .017); whereas TOS and OSI levels were significantly higher (p = .003 and p = .008). Multivariable logistic regression analysis revealed ADAMTS5 and TOS levels were independently associated with adverse perinatal outcomes (p = .004 and p = .018). We found that serum ADAMTS5 levels decreased and TOS level increased in GDM pregnant at 24-28th gestational weeks. In addition, we found that increased levels of serum ADAMTS5 and decreased TOS levels at 24-28th weeks were associated with adverse perinatal outcomes independent of the mode of treatment in GDM.Impact statement What is already known on this subject? Gestational diabetes mellitus (GDM) is one of the most common medical complications of pregnancy. The insulin resistance, which starts at the 24-28th gestational weeks, increases during gestation. GDM increases maternal complications like preeclampsia, cesarean rate, cardiovascular disease, obesity, and diabetes after pregnancy; and neonatal complications like macrosomia, hypoglycemia, hyperbilirubinemia, delivery trauma, shoulder dystocia, and adult-onset obesity, and diabetes. What the results of this study add? A significant relationship between ADAMTS5, TOS levels and adverse perinatal outcome. insulin resistance and was observed. WOS:000486770000001 31526197 Q4 |
| وصف الملف: | application/pdf |
| تدمد: | 1364-6893 0144-3615 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b335f32a057adb502730a1198af4759Test https://doi.org/10.1080/01443615.2019.1634025Test |
| حقوق: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....9b335f32a057adb502730a1198af4759 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 13646893 01443615 |
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