Circulating asymmetric dimethylarginine, endothelin-1 and cell adhesion molecules in women with gestational diabetes
| العنوان: | Circulating asymmetric dimethylarginine, endothelin-1 and cell adhesion molecules in women with gestational diabetes |
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| المؤلفون: | Anna Modzelewska, Mariusz Kuzmicki, Maria Gorska, Anna Zonenberg, Beata Telejko, Agnieszka Ponurkiewicz, Karolina Niedziolko-Bagniuk, Agnieszka Nikolajuk |
| المصدر: | Acta Diabetologica. 46:303-308 |
| بيانات النشر: | Springer Science and Business Media LLC, 2009. |
| سنة النشر: | 2009 |
| مصطلحات موضوعية: | Adult, Blood Glucose, medicine.medical_specialty, Endocrinology, Diabetes and Metabolism, Vascular Cell Adhesion Molecule-1, Arginine, chemistry.chemical_compound, Endocrinology, Pregnancy, Internal medicine, Diabetes mellitus, E-selectin, Internal Medicine, Humans, Medicine, Endothelin-1, biology, business.industry, Case-control study, Gestational age, General Medicine, medicine.disease, Endothelin 1, Gestational diabetes, Diabetes, Gestational, chemistry, Case-Control Studies, biology.protein, Female, business, Asymmetric dimethylarginine |
| الوصف: | We measured plasma concentrations of asymmetric dimethylarginine (ADMA), endothelin-1 (ET-1), soluble vascular cell adhesion molecule-1 (sVCAM-1) and E-selectin in 56 patients with gestational diabetes (GDM), 68 pregnant women with normal glucose tolerance (NGT) and 36 healthy non-pregnant women. ADMA concentrations were markedly lower in NGT [0.48 (0.42-0.55) micromol/l] than in GDM subjects [0.50 (0.43-0.67) micromol/l] and healthy controls [0.57 (0.46-0.72) micromol/l, P = 0.005]. ET-1 levels were comparable between GDM [0.76 (0.58-0.90) pg/ml] and NGT women [0.75 (0.63-0.92) pg/ml] and significantly higher than in the non-pregnant subjects [0.62 (0.52-0.72) pg/ml, P = 0.007 and P = 0.005, respectively]. There were no differences in sVCAM-1 and E-selectin levels between the groups studied. ADMA levels were significantly associated with fasting glucose (beta = 0.23, P = 0.02) and gestational age (beta = 0.24, P = 0.01). Our results suggest that physiological adaptation to pregnancy is associated with a fall in circulating ADMA and an elevation of ET-1 concentrations, irrespective of the disturbances of glucose tolerance. |
| تدمد: | 1432-5233 0940-5429 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a9cdff24d460fed425b7fab763ac527Test https://doi.org/10.1007/s00592-008-0088-xTest |
| حقوق: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....9a9cdff24d460fed425b7fab763ac527 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14325233 09405429 |
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