Serum Metabolic Profiles of the Tryptophan-Kynurenine Pathway in the high risk subjects of major depressive disorder
| العنوان: | Serum Metabolic Profiles of the Tryptophan-Kynurenine Pathway in the high risk subjects of major depressive disorder |
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| المؤلفون: | Akihiro Mouri, Kuniaki Saito, Toshitaka Nabeshima, Hiroyuki Kimura, Tomoya Miyauchi, Takashi Tonoike, Norio Ozaki, Eri Umemura, Yasuko Yamamoto, Hidetoshi Matsunami, Masashi Sakurai, Noriyo Kanayama, Kenichi Kurita, Masaya Hasegawa, Wataru Nagashima, Masao Takemura, Aiji Sato Boku, Mikiko Ito, Tatsuya Tokura |
| المصدر: | Scientific Reports, Vol 10, Iss 1, Pp 1-13 (2020) Scientific Reports |
| بيانات النشر: | Springer Science and Business Media LLC, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Male, 0301 basic medicine, Kynurenine pathway, Metabolite, 3-Hydroxyanthranilic Acid, lcsh:Medicine, Kynurenic Acid, Mice, chemistry.chemical_compound, 0302 clinical medicine, Kynurenic acid, ortho-Aminobenzoates, lcsh:Science, Kynurenine, Multidisciplinary, Depression, Tryptophan, Chronic pain, Middle Aged, Healthy Volunteers, Metabolome, Biomarker (medicine), Major depressive disorder, Female, Chronic Pain, Adult, medicine.medical_specialty, Predictive markers, Article, 03 medical and health sciences, Internal medicine, medicine, Animals, Humans, Psychiatric Status Rating Scales, Depressive Disorder, Major, business.industry, lcsh:R, Case-control study, medicine.disease, Disease Models, Animal, Interleukin 1 Receptor Antagonist Protein, 030104 developmental biology, Endocrinology, chemistry, Case-Control Studies, lcsh:Q, business, Biomarkers, Stress, Psychological, 030217 neurology & neurosurgery |
| الوصف: | Previous reports have shown that during chronic inflammation, the tryptophan (TRP)-kynurenine (KYN) pathway plays a pivotal role in the onset of depression. The aim of this study was to investigate the characteristics of the serum TRP-KYN pathway metabolite profile in high-risk subjects of major depressive disorder (HRMDD) defined by depression scores. The concentrations of TRP-KYN pathway metabolites {TRP, KYN, 3-hydroxyanthranilic acid (3HAA), 3-hydroxykynurenine (3HK), kynurenic acid (KYNA) and anthranilic acid (AA)} were assessed in serum from HRMDD, chronic pain disorder patients and healthy controls. In serum from HRMDD, elevated levels of AA and decreased levels of TRP were observed, but the levels of other metabolites were not changed. Furthermore, the change in the AA2nd/AA1st ratio in subjects who progressed from a healthy state to a depressive state was correlated with an increase in the CES-D score. The level of IL-1 receptor antagonist (IL-1RA) was negatively correlated with that of AA. Interestingly, we confirmed AA as a possible biomarker for depression-related symptoms, since the metabolite profiles in the chronic pain disorder group and chronic unpredictable mild stress model mice were similar to those in the HRMDD. These results suggest that AA may be an effective marker for HRMDD. |
| تدمد: | 2045-2322 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a338e9597555d6f19213b395d5e7bcaTest https://doi.org/10.1038/s41598-020-58806-wTest |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....9a338e9597555d6f19213b395d5e7bca |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20452322 |
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