IKZF1 polymorphisms are associated with susceptibility, cytokine levels, and clinical features in systemic lupus erythematosus
| العنوان: | IKZF1 polymorphisms are associated with susceptibility, cytokine levels, and clinical features in systemic lupus erythematosus |
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| المؤلفون: | Zhuochun Huang, Junlong Zhang, Lin Chen, Yongkang Wu, Qian Niu, Bin Yang |
| المصدر: | Medicine |
| بيانات النشر: | Lippincott Williams & Wilkins, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Adult, Male, medicine.medical_treatment, Observational Study, Single-nucleotide polymorphism, Polymorphism, Single Nucleotide, Linkage Disequilibrium, Pathogenesis, 03 medical and health sciences, single nucleotide polymorphisms, Ikaros Transcription Factor, Young Adult, 0302 clinical medicine, systemic lupus erythematosus, granzyme B, Medicine, Humans, Lupus Erythematosus, Systemic, Genetic Predisposition to Disease, 030212 general & internal medicine, skin and connective tissue diseases, Lupus erythematosus, business.industry, Case-control study, Lymphocyte differentiation, General Medicine, ikaros family zinc finger 1, Middle Aged, medicine.disease, malar rash, Granzyme B, Cytokine, hematological disorder, 030220 oncology & carcinogenesis, Case-Control Studies, Immunology, Cytokines, Female, medicine.symptom, CD40 ligand, business, Malar rash, Research Article |
| الوصف: | Ikaros family zinc finger 1(IKZF1) encodes a lymphoid-restricted zinc finger transcription factor named Ikaros that regulates lymphocyte differentiation and proliferation as well as self-tolerance. Increasing evidence indicates that IKZF1 could contribute to the pathogenesis of autoimmune diseases. Recent research has provided evidence that IKZF1 might correlate with Systemic lupus erythematosus (SLE), but no clear definition has been made yet. In this study, we focus on the relationship between IKZF1 polymorphisms and SLE susceptibility, cytokine levels, and clinical characteristics in the Chinese Han population. One thousand seventy-six subjects, including 400 SLE patients and 676 healthy controls, were included in this study. Three single nucleotide polymorphisms within IKZF1 containing rs4917014, rs11980379, and rs4132601 were genotyped in all subjects by an improved multiplex ligation detection reaction technique. 143 subjects from SLE patients were randomly selected for testing the levels of serum cytokines. The clinical characteristics of SLE patients were gathered and collated from medical records. The data were analyzed mainly using SPSS20.0 (SPSS lnc., Chicago, IL). Significant relationships were observed between rs4132601 and SLE susceptibility, CD40 ligand, and malar rash (P |
| اللغة: | English |
| تدمد: | 1536-5964 0025-7974 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a27d1d5a0f39fac36f82354f7f53864Test http://europepmc.org/articles/PMC7544280Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....9a27d1d5a0f39fac36f82354f7f53864 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15365964 00257974 |
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