Continuous Exposure to Alpha-Glycosyl Isoquercitrin from Gestation Ameliorates Disrupted Hippocampal Neurogenesis in Rats Induced by Gestational Injection of Valproic Acid
| العنوان: | Continuous Exposure to Alpha-Glycosyl Isoquercitrin from Gestation Ameliorates Disrupted Hippocampal Neurogenesis in Rats Induced by Gestational Injection of Valproic Acid |
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| المؤلفون: | Kazumi Takashima, Hiromu Okano, Ryota Ojiro, Qian Tang, Yasunori Takahashi, Shunsuke Ozawa, Xinyu Zou, Mihoko Koyanagi, Robert R. Maronpot, Toshinori Yoshida, Makoto Shibutani |
| المصدر: | Neurotoxicity Research. 40:2278-2296 |
| بيانات النشر: | Springer Science and Business Media LLC, 2022. |
| سنة النشر: | 2022 |
| مصطلحات موضوعية: | Autism Spectrum Disorder, Valproic Acid, Neurogenesis, General Neuroscience, Toxicology, Hippocampus, Antioxidants, Rats, Pregnancy, Prenatal Exposure Delayed Effects, Humans, Animals, Female, Ciliary Neurotrophic Factor |
| الوصف: | This study examined the ameliorating effect of alpha-glycosyl isoquercitrin (AGIQ), an antioxidant, on disrupted hippocampal neurogenesis in the dentate gyrus (DG) in a rat model of autism spectrum disorder induced by prenatal valproic acid (VPA) exposure. Dams were intraperitoneally injected with 500 mg/kg VPA on gestational day 12. AGIQ was administered in the diet at 0.25 or 0.5% to dams from gestational day 13 until weaning at postnatal day (PND) 21 and then to pups until PND 63. At PND 21, VPA-exposed offspring showed decreased numbers of type-2a and type-3 neural progenitor cells (NPCs) among granule cell lineage subpopulations. AGIQ treatment at both doses rescued the reduction in type-3 NPCs. AGIQ upregulated Reln and Vldlr transcript levels in the DG at 0.5% and ≥ 0.25%, respectively, and increased the number of reelin |
| تدمد: | 1476-3524 1029-8428 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99ef35d9d6db74e63e76f56d79c21179Test https://doi.org/10.1007/s12640-022-00574-8Test |
| حقوق: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....99ef35d9d6db74e63e76f56d79c21179 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14763524 10298428 |
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