MYC/BCL2 protein coexpression contributes to the inferior survival of activated B-cell subtype of diffuse large B-cell lymphoma and demonstrates high-risk gene expression signatures:a report from The International DLBCL Rituximab-CHOP Consortium Program
| العنوان: | MYC/BCL2 protein coexpression contributes to the inferior survival of activated B-cell subtype of diffuse large B-cell lymphoma and demonstrates high-risk gene expression signatures:a report from The International DLBCL Rituximab-CHOP Consortium Program |
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| المؤلفون: | Karen Dybkær, William W.L. Choi, Yong Li, J. Han van Krieken, Meifeng Tu, Zijun Y. Xu-Monette, L. Jeffrey Medeiros, Weina Chen, April Chiu, Andrés J.M. Ferreri, Aarthi Balasubramanyam, Miguel A. Piris, Randy D. Gascoyne, Jooryung Huh, Fan Zhou, Govind Bhagat, Eric D. Hsi, Weiyun Z. Ai, Carlo Visco, Lin Wu, Qin Huang, Graham W. Slack, Maurilio Ponzoni, Ronald S. Go, Kristy L. Richards, Michael Boe Møller, Attilio Orazi, Youli Zu, Ken H. Young, Xiaoying Zhao, Santiago Montes-Moreno, Roberto N. Miranda, Daina Variakojis, Alexander Tzankov, Shimin Hu, Tina Green, Wei-Min Liu |
| المساهمون: | Hu, S, Xu Monette, Zy, Tzankov, A, Green, T, Wu, L, Balasubramanyam, A, Liu, Wm, Visco, C, Li, Y, Miranda, Rn, Montes Moreno, S, Dybkaer, K, Chiu, A, Orazi, A, Zu, Y, Bhagat, G, Richards, Kl, Hsi, Ed, Choi, Ww, Zhao, X, van Krieken, Jh, Huang, Q, Huh, J, Ai, W, Ponzoni, Maurilio, Ferreri, Aj, Zhou, F, Slack, Gw, Gascoyne, Rd, Tu, M, Variakojis, D, Chen, W, Go, R, Piris, Ma, Møller, Mb, Medeiros, Lj, Young, Kh |
| المصدر: | Hu, S, Xu-Monette, Z Y, Tzankov, A, Green, T, Wu, L, Balasubramanyam, A, Liu, W, Visco, C, Li, Y, Miranda, R N, Montes-Moreno, S, Dybkaer, K, Chiu, A, Orazi, A, Zu, Y, Bhagat, G, Richards, K L, Hsi, E D, Choi, W W L, Zhao, X, van Krieken, J H, Huang, Q, Huh, J, Ai, W, Ponzoni, M, Ferreri, A J M, Zhou, F, Slack, G W, Gascoyne, R D, Tu, M, Variakojis, D, Chen, W, Go, R S, Piris, M A, Møller, M B, Medeiros, L J & Young, K H 2013, ' MYC/BCL2 protein coexpression contributes to the inferior survival of activated B-cell subtype of diffuse large B-cell lymphoma and demonstrates high-risk gene expression signatures : a report from The International DLBCL Rituximab-CHOP Consortium Program ', Blood, vol. 121, no. 20, pp. 4021-31; quiz 4250 . https://doi.org/10.1182/blood-2012-10-460063Test Blood, 121, 4021-31 Hu, S, Xu-Monette, Z Y, Tzankov, A, Green, T, Wu, L, Balasubramanyam, A, Liu, W, Visco, C, Li, Y, Miranda, R N, Montes-Moreno, S, Dybkær, K, Chiu, A, Orazi, A, Zu, Y, Bhagat, G, Richards, K L, Hsi, E D, Choi, W W L, Zhao, X, van Krieken, J H, Huang, Q, Huh, J, Ai, W, Ponzoni, M, Ferreri, A J M, Zhou, F, Slack, G W, Gascoyne, R D, Tu, M, Variakojis, D, Chen, W, Go, R S, Piris, M A, Møller, M, Medeiros, L J & Young, K H 2013, ' MYC/BCL2 protein coexpression contributes to the inferior survival of activated B-cell subtype of diffuse large B-cell lymphoma and demonstrates high-risk gene expression signatures : a report from The International DLBCL Rituximab-CHOP Consortium Program ', Blood, vol. 121, no. 20, pp. 4021-31; quiz 4250 . https://doi.org/10.1182/blood-2012-10-460063Test Blood, 121, 20, pp. 4021-31 |
| سنة النشر: | 2013 |
| مصطلحات موضوعية: | Male, Lymphoma, International Cooperation, Plenary Paper, CHOP, Lymphocyte Activation, Biochemistry, Cohort Studies, Antibodies, Monoclonal, Murine-Derived, immune system diseases, Risk Factors, hemic and lymphatic diseases, Monoclonal, Antineoplastic Combined Chemotherapy Protocols, 80 and over, Regulation of gene expression, Aged, 80 and over, Hematology, Adult, Aged, B-Lymphocyte Subsets, Cyclophosphamide, Doxorubicin, Female, Gene Expression Regulation, Neoplastic, Humans, Lymphoma, Large B-Cell, Diffuse, Middle Aged, Prednisone, Prognosis, Proto-Oncogene Proteins c-bcl-2, Proto-Oncogene Proteins c-myc, Retrospective Studies, Rituximab, Survival Analysis, Vincristine, Transcriptome, Translational research Tissue engineering and pathology [ONCOL 3], Diffuse, medicine.anatomical_structure, biological phenomena, cell phenomena, and immunity, medicine.drug, Murine-Derived, Immunology, Biology, Antibodies, Large B-Cell, medicine, neoplasms, B cell, Neoplastic, Germinal center, Cell Biology, medicine.disease, Gene Expression Regulation, Cancer research, Diffuse large B-cell lymphoma |
| الوصف: | Contains fulltext : 118768.pdf (Publisher’s version ) (Closed access) Diffuse large B-cell lymphoma (DLBCL) is stratified into prognostically favorable germinal center B-cell (GCB)-like and unfavorable activated B-cell (ABC)-like subtypes based on gene expression signatures. In this study, we analyzed 893 de novo DLBCL patients treated with R-CHOP (rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone). We show that MYC/BCL2 protein coexpression occurred significantly more commonly in the ABC subtype. Patients with the ABC or GCB subtype of DLBCL had similar prognoses with MYC/BCL2 coexpression and without MYC/BCL2 coexpression. Consistent with the notion that the prognostic difference between the 2 subtypes is attributable to MYC/BCL2 coexpression, there is no difference in gene expression signatures between the 2 subtypes in the absence of MYC/BCL2 coexpression. DLBCL with MYC/BCL2 coexpression demonstrated a signature of marked downregulation of genes encoding extracellular matrix proteins, those involving matrix deposition/remodeling and cell adhesion, and upregulation of proliferation-associated genes. We conclude that MYC/BCL2 coexpression in DLBCL is associated with an aggressive clinical course, is more common in the ABC subtype, and contributes to the overall inferior prognosis of patients with ABC-DLBCL. In conclusion, the data suggest that MYC/BCL2 coexpression, rather than cell-of-origin classification, is a better predictor of prognosis in patients with DLBCL treated with R-CHOP. |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 0006-4971 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99d9dd7f33155bb9725d31b8b25e01ceTest https://portal.findresearcher.sdu.dk/da/publications/9de4f293-a230-45c6-b8bb-ee74c81c0747Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....99d9dd7f33155bb9725d31b8b25e01ce |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 00064971 |
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