Retrospective Analysis of Cerebrospinal Fluid Profiles in 228 Patients with Leptomeningeal Carcinomatosis : Differences According to the Sampling Site, Symptoms, and Systemic Factors
| العنوان: | Retrospective Analysis of Cerebrospinal Fluid Profiles in 228 Patients with Leptomeningeal Carcinomatosis : Differences According to the Sampling Site, Symptoms, and Systemic Factors |
|---|---|
| المؤلفون: | Jungnam Joo, Ho-Shin Gwak, Sanghoon Shin, Heon Yoo, Youngbo Shim, Sohee Kim |
| المصدر: | Journal of Korean Neurosurgical Society |
| بيانات النشر: | The Korean Neurosurgical Society, 2016. |
| سنة النشر: | 2016 |
| مصطلحات موضوعية: | Pathology, medicine.medical_specialty, Cauda equina syndrome, Gastroenterology, 03 medical and health sciences, 0302 clinical medicine, Cerebrospinal fluid, Lumbar, Internal medicine, medicine, Ommaya reservoir, Leptomeningeal carcinomatosis, CSF albumin, Intracranial pressure, Clinical Article, medicine.diagnostic_test, Lumbar puncture, business.industry, General Neuroscience, Ventricular, medicine.disease, Hydrocephalus, 030220 oncology & carcinogenesis, Surgery, Neurology (clinical), business, 030217 neurology & neurosurgery |
| الوصف: | OBJECTIVE Elevated cell counts and protein levels in cerebrospinal fluid (CSF) result from disease activity in patients with leptomeningeal carcinomatosis (LMC). Previous studies evaluated the use of CSF profiles to monitor a treatment response or predict prognosis. CSF profiles vary, however, according to the sampling site and the patient's systemic condition. We compared lumbar and ventricular CSF profiles collected before intraventricular chemotherapy for LMC and evaluated the association of these profiles with patients' systemic factors and LMC disease activity. METHODS CSF profiles were retrospectively collected from 228 patients who underwent Ommaya reservoir insertion for intraventricular chemotherapy after a diagnosis of LMC. Lumbar samples taken via lumbar puncture were used for the diagnosis, and ventricular samples were obtained later at the time of Ommaya reservoir insertion. LMC disease activity was defined as the presence of LMC-related symptoms such as increased intracranial pressure, hydrocephalus, cranial neuropathy, and cauda equina syndrome. RESULTS Cell counts (median : 8 vs. 1 cells/mL) and protein levels (median : 68 vs. 17 mg/dL) significantly higher in lumbar CSF than in ventricular CSF (p |
| اللغة: | English |
| تدمد: | 1598-7876 2005-3711 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::992c1e9ea9d9026ebcb5d96a5acced5fTest http://europepmc.org/articles/PMC5106355Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....992c1e9ea9d9026ebcb5d96a5acced5f |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15987876 20053711 |
|---|