Urinary Transferrin Excretion in Type 1 (Insulin-dependent) Diabetes Mellitus
| العنوان: | Urinary Transferrin Excretion in Type 1 (Insulin-dependent) Diabetes Mellitus |
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| المؤلفون: | A. H. Barnett, C Chapman, M.J. Toop, C.M. Florkowski, M.J. O'Donnell, P Martin, R. Holder |
| المصدر: | Diabetic Medicine. 8:657-661 |
| بيانات النشر: | Wiley, 1991. |
| سنة النشر: | 1991 |
| مصطلحات موضوعية: | Adult, Blood Glucose, Male, medicine.medical_specialty, Endocrinology, Diabetes and Metabolism, Serum albumin, Urine, Excretion, chemistry.chemical_compound, Endocrinology, Reference Values, Internal medicine, Diabetes mellitus, Acetylglucosaminidase, Internal Medicine, medicine, Albuminuria, Humans, Diabetic Nephropathies, Serum Albumin, Glycated Hemoglobin, chemistry.chemical_classification, Analysis of Variance, Creatinine, Type 1 diabetes, Diabetic Retinopathy, biology, business.industry, Transferrin, medicine.disease, Diabetes Mellitus, Type 1, chemistry, biology.protein, Female, medicine.symptom, business, Biomarkers |
| الوصف: | Urinary excretion of transferrin and albumin was studied by radioimmunoassay in 47 adult patients with Type 1 diabetes and 28 control subjects. Median (range) urinary transferrin excretion rate was significantly elevated in the diabetic group 0.58 (0.02-2663.3) micrograms min-1 compared with the control group 0.04 (0.01-0.28) micrograms min-1, p less than 0.001. Urinary transferrin:creatinine ratios (x 10(2)) were different in diabetic 47 (0.6-958.0) micrograms mmol-1 and control groups 0.7 (0.06-2.3) micrograms mmol-1, p less than 0.001). There were correlations between urinary transferrin and albumin excretion rates in diabetic (r = 0.78, p less than 0.001) and control groups (r = 0.81, p less than 0.05). Forty (85%) diabetic patients had elevated transferrin excretion rates, 18 (38.3%) had elevated albumin excretion rates. All diabetic patients with elevated albumin excretion rates had elevated transferrin excretion rates. Twenty-one (77.8%) of the patients with normal albumin excretion rates had elevated transferrin excretion rates. Urinary excretion of N-acetyl-beta-D-glucosaminidase was greater in diabetic patients than control subjects (142 vs 58 mumol h-1 l-1, p less than 0.001). There were correlation between transferrin and N-acetyl-beta-D-glucosaminidase excretion (r = 0.67, p less than 0.01) and albumin and N-acetyl-beta-D-glucosaminidase excretion (r = 0.63, p less than 0.01) in the diabetic group. Elevated urinary transferrin excretion rate may be a marker for renal dysfunction in diabetes mellitus. |
| تدمد: | 1464-5491 0742-3071 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98bf61259de1dd27c38f3912606591c5Test https://doi.org/10.1111/j.1464-5491.1991.tb01673.xTest |
| حقوق: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....98bf61259de1dd27c38f3912606591c5 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14645491 07423071 |
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