Perfusion and Metabolic Neuromonitoring during Ventricular Taps in Infants with Post-Hemorrhagic Ventricular Dilatation
| العنوان: | Perfusion and Metabolic Neuromonitoring during Ventricular Taps in Infants with Post-Hemorrhagic Ventricular Dilatation |
|---|---|
| المؤلفون: | Victor K. Han, Marcus Lo, Mamadou Diop, Lawrence C. M. Yip, Matthew Kewin, Sandrine de Ribaupierre, Ajay Rajaram, Jeffrey J. L. Carson, Daniel Milej, Soume Bhattacharya, Keith St. Lawrence, Marianne Suwalski |
| المصدر: | Brain Sciences Volume 10 Issue 7 Brain Sciences, Vol 10, Iss 452, p 452 (2020) Paediatrics Publications |
| بيانات النشر: | MDPI, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | medicine.medical_specialty, Neonatal intensive care unit, near-infrared spectroscopy, cerebral blood flow, Pediatrics, 01 natural sciences, Article, lcsh:RC321-571, 010309 optics, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, cytochrome c oxidase, 0103 physical sciences, medicine, Cerebral perfusion pressure, lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry, Intracranial pressure, diffuse correlation spectroscopy, business.industry, intraventricular hemorrhaging, General Neuroscience, Ventricular dilatation, Diffuse correlation spectroscopy, medicine.disease, ventricular tap, 3. Good health, Hydrocephalus, premature brain injury, Cerebral blood flow, Cardiology, business, hydrocephalus, Perfusion, metabolism, 030217 neurology & neurosurgery, neuromonitoring |
| الوصف: | Post-hemorrhagic ventricular dilatation (PHVD) is characterized by a build-up of cerebral spinal fluid (CSF) in the ventricles, which increases intracranial pressure and compresses brain tissue. Clinical interventions (i.e., ventricular taps, VT) work to mitigate these complications through CSF drainage however, the timing of these procedures remains imprecise. This study presents Neonatal NeuroMonitor (NNeMo), a portable optical device that combines broadband near-infrared spectroscopy (B-NIRS) and diffuse correlation spectroscopy (DCS) to provide simultaneous assessments of cerebral blood flow (CBF), tissue saturation (StO2), and the oxidation state of cytochrome c oxidase (oxCCO). In this study, NNeMo was used to monitor cerebral hemodynamics and metabolism in PHVD patients selected for a VT. Across multiple VTs in four patients, no significant changes were found in any of the three parameters: CBF increased by 14.6 ± 37.6% (p = 0.09), StO2 by 1.9 ± 4.9% (p = 0.2), and oxCCO by 0.4 ± 0.6 µ M (p = 0.09). However, removing outliers resulted in significant, but small, increases in CBF (6.0 ± 7.7%) and oxCCO (0.1 ± 0.1 µ M). The results of this study demonstrate NNeMo&rsquo s ability to provide safe, non-invasive measurements of cerebral perfusion and metabolism for neuromonitoring applications in the neonatal intensive care unit. |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 2076-3425 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96e8aa3f27d0e5c177ef91945c58aec0Test http://europepmc.org/articles/PMC7407524Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....96e8aa3f27d0e5c177ef91945c58aec0 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20763425 |
|---|