Investigation of Causal Effects of Protein Biomarkers on Cardiovascular Disease in Persons With HIV
| العنوان: | Investigation of Causal Effects of Protein Biomarkers on Cardiovascular Disease in Persons With HIV |
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| المؤلفون: | Cavan S Reilly, Álvaro H Borges, Jason V Baker, Sandra E Safo, Shweta Sharma, Mark N Polizzotto, James S Pankow, Xiaojun Hu, Brad T Sherman, Abdel G Babiker, Jens D Lundgren, H Clifford Lane |
| المصدر: | The Journal of Infectious Diseases. 227:951-960 |
| بيانات النشر: | Oxford University Press (OUP), 2022. |
| سنة النشر: | 2022 |
| مصطلحات موضوعية: | Infectious Diseases, Immunology and Allergy |
| الوصف: | Background There is an incompletely understood increased risk for cardiovascular disease (CVD) among people with HIV (PWH). We investigated if a collection of biomarkers were associated with CVD among PWH. Mendelian randomization (MR) was used to identify potentially causal associations. Methods Data from follow-up in 4 large trials among PWH were used to identify 131 incident CVD cases and they were matched to 259 participants without incident CVD (controls). Tests of associations between 460 baseline protein levels and case status were conducted. Results Univariate analysis found CLEC6A, HGF, IL-6, IL-10RB, and IGFBP7 as being associated with case status and a multivariate model identified 3 of these: CLEC6A (odds ratio [OR] = 1.48, P = .037), HGF (OR = 1.83, P = .012), and IL-6 (OR = 1.45, P = .016). MR methods identified 5 significantly associated proteins: AXL, CHI3L1, GAS6, IL-6RA, and SCGB3A2. Conclusions These results implicate inflammatory and fibrotic processes as contributing to CVD. While some of these biomarkers are well established in the general population and in PWH (IL-6 and its receptor), some are novel to PWH (HGF, AXL, and GAS6) and some are novel overall (CLEC6A). Further investigation into the uniqueness of these biomarkers in PWH and the role of these biomarkers as targets among PWH is warranted. |
| تدمد: | 1537-6613 0022-1899 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96a4ebf9d66082967a574dac2d266e06Test https://doi.org/10.1093/infdis/jiac496Test |
| حقوق: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....96a4ebf9d66082967a574dac2d266e06 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15376613 00221899 |
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