A Novel Systematic Oxidative Stress Score Predicts the Prognosis of Patients with Operable Breast Cancer
| العنوان: | A Novel Systematic Oxidative Stress Score Predicts the Prognosis of Patients with Operable Breast Cancer |
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| المؤلفون: | Xiangsheng Xiao, Jun Tang, Xi Wang, Weidong Wei, Liqin Ping, Gehao Liang, Yan Wang, Xiaoming Xie, Tian Du, Kaiming Zhang, Ya Sun |
| المصدر: | Oxidative Medicine and Cellular Longevity Oxidative Medicine and Cellular Longevity, Vol 2021 (2021) |
| بيانات النشر: | Hindawi, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Oncology, Aging, medicine.medical_specialty, Article Subject, Breast Neoplasms, medicine.disease_cause, Biochemistry, chemistry.chemical_compound, Breast cancer, Internal medicine, Lactate dehydrogenase, medicine, Humans, Blood urea nitrogen, Creatinine, QH573-671, business.industry, Area under the curve, Cell Biology, General Medicine, Nomogram, Middle Aged, medicine.disease, Prognosis, Survival Analysis, Oxidative Stress, chemistry, Female, Cytology, business, TBIL, Oxidative stress, Research Article |
| الوصف: | Background. Breast cancer was associated with imbalance between oxidation and antioxidation. Local oxidative stress in tumors is closely related to the occurrence and development of breast cancer. However, the relationship between systematic oxidative stress and breast cancer remains unclear. This study is aimed at exploring the prognostic value of systematic oxidative stress in patients with operable breast cancer. Methods. A total of 1583 operable female breast cancer patients were randomly assigned into the training set and validation set. The relationship between systematic oxidative stress biomarkers and prognosis were analyzed in the training and validation sets. Results. The systematic oxidative stress score (SOS) was established based on five systematic oxidative stress biomarkers including serum creatinine (CRE), serum albumin (ALB), total bilirubin (TBIL), lactate dehydrogenase (LDH), and blood urea nitrogen (BUN). SOS was an independent prognostic factor for operable breast cancer patients. A nomogram based on SOS and clinical characteristics could accurately predict the prognosis of operable breast cancer patients, and the area under the curve (AUC) of the nomogram was 0.823 in the training set and 0.872 in the validation set, which was much higher than the traditional prognostic indicators. Conclusions. SOS is an independent prognostic indicator for operable breast cancer patients. A prediction model based on SOS could accurately predict the outcome of operable breast cancer patients. |
| وصف الملف: | text/xhtml |
| اللغة: | English |
| تدمد: | 1942-0994 1942-0900 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95f6c98d5ab1110ed6950871b32a52e0Test http://europepmc.org/articles/PMC8516560Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....95f6c98d5ab1110ed6950871b32a52e0 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 19420994 19420900 |
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