Chemical Discrimination of Astragalus mongholicus and Astragalus membranaceus Based on Metabolomics Using UHPLC-ESI-Q-TOF-MS/MS Approach
| العنوان: | Chemical Discrimination of Astragalus mongholicus and Astragalus membranaceus Based on Metabolomics Using UHPLC-ESI-Q-TOF-MS/MS Approach |
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| المؤلفون: | Liu Qi, Wang Yumei, Jicheng Liu, Yu Sun, Lei Liu, Yukun Ma, Li-Na Guo |
| المصدر: | Molecules Volume 24 Issue 22 Molecules, Vol 24, Iss 22, p 4064 (2019) |
| بيانات النشر: | Multidisciplinary Digital Publishing Institute, 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | Sophoricoside, Electrospray ionization, Pharmaceutical Science, Coumaric acid, Mass spectrometry, Analytical Chemistry, lcsh:QD241-441, 03 medical and health sciences, chemistry.chemical_compound, Astragalus mongholicus, 0302 clinical medicine, Astragaloside, Metabolomics, lcsh:Organic chemistry, Drug Discovery, Formononetin, Physical and Theoretical Chemistry, constituents, 030304 developmental biology, 0303 health sciences, Chromatography, biology, Organic Chemistry, biology.organism_classification, metabolomics, Astragalus, chemistry, Chemistry (miscellaneous), 030220 oncology & carcinogenesis, Astragalus membranaceus, Molecular Medicine, ultra-high performance liquid chromatography coupled with electrospray ionization/quadrupoletime-of-flight mass spectrometry, discrimination |
| الوصف: | Astragalus mongholicus (MG) and Astragalus membranaceus (MJ), both generally known as Huangqi in China, are two perennial herbals widely used in variety diseases. However, there were still some differences in the chemical ingredients between MG and MJ. In this paper, metabolomics combined with the ultra-high performance liquid chromatography coupled with electrospray ionization/quadrupole time-of-flight mass spectrometry (UHPLC-ESI-Q-TOF-MS/MS) was employed to contrastively analyze the chemical constituents between MG and MJ. As a result, principal component analysis showed that MG and MJ were separated clearly. A total of 53 chemical markers were successfully identified for the discrimination of MG and MJ. Of them, the contents of 36 components including Astragaloside I~III, Astragaloside IV, Agroastragaloside I, etc. in MJ were significantly higher than those in MG. On the contrary, the contents of 17 other components including coumaric acid, formononetin, sophoricoside, etc. in MG were obviously higher than those in MJ. The results showed that the distinctive constituents in MG and MJ were remarkable, and MJ may own stronger pharmacological activities than MG. In a word, MG and MJ may be treated as two different herbs. This paper demonstrated that metabolomics was a vitally credible technology to rapidly screen the characteristic chemical composition of traditional Chinese medicine. |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 1420-3049 |
| DOI: | 10.3390/molecules24224064 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95834d83ab672e0f41bacbc21cbe746eTest |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....95834d83ab672e0f41bacbc21cbe746e |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14203049 |
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| DOI: | 10.3390/molecules24224064 |