Pulmonary function and CT biomarkers as risk factors for cardiovascular events in male lung cancer screening participants : the NELSON study
| العنوان: | Pulmonary function and CT biomarkers as risk factors for cardiovascular events in male lung cancer screening participants : the NELSON study |
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| المؤلفون: | Ivana Išgum, Firdaus A. A. Mohamed Hoesein, Rozemarijn Vliegenthart, Bram van Ginneken, Eva M. van Rikxoort, Harry J. de Koning, Matthijs Oudkerk, Pieter Zanen, Richard A.P. Takx, Carlijn M. van der Aalst, Tim Leiner, Willem P.Th.M. Mali, Jan-Willem J. Lammers, Michael Schmidt, Pim A. de Jong, Harry J.M. Groen |
| المساهمون: | Public Health, Basic and Translational Research and Imaging Methodology Development in Groningen (BRIDGE), Cardiovascular Centre (CVC), Publica, Academic Medical Center |
| المصدر: | European Radiology, 25(1), 65-71. Springer-Verlag European Radiology, 25, pp. 65-71 European Radiology, 25, 65-71 European Radiology, 25(1), 65. Springer Verlag European Radiology, 25(1), 65-71. SPRINGER European radiology, 25(1), 65-71. Springer Verlag |
| سنة النشر: | 2015 |
| مصطلحات موضوعية: | Male, SYSTEMIC INFLAMMATION, Lung Neoplasms, Heart disease, genetic structures, PREDICTION, Vital Capacity, EMPHYSEMA, Pulmonary function testing, law.invention, Belgium, Randomized controlled trial, Risk Factors, law, Forced Expiratory Volume, Early Detection of Cancer, Netherlands, Neuroradiology, medicine.diagnostic_test, Incidence, Incidence (epidemiology), Smoking, General Medicine, Middle Aged, respiratory system, Prognosis, Cardiovascular diseases, Radiology, Rare cancers Radboud Institute for Health Sciences [Radboudumc 9], Spirometry, medicine.medical_specialty, COMPUTED-TOMOGRAPHY SCANS, Multi-detector computed tomography, HEART-DISEASE, Imaging, Three-Dimensional, SDG 3 - Good Health and Well-being, CORONARY-ARTERY CALCIUM, medicine, Humans, Radiology, Nuclear Medicine and imaging, Mass screening, DECLINE, business.industry, MORTALITY, medicine.disease, respiratory tract diseases, FUNCTION IMPAIRMENT, Tomography, X-Ray Computed, business, Lung cancer screening |
| الوصف: | Contains fulltext : 153772.pdf (Publisher’s version ) (Open Access) The objective of this study was to investigate the association of spirometry and pulmonary CT biomarkers with cardiovascular events.In this lung cancer screening trial 3,080 male participants without a prior cardiovascular event were analysed. Fatal and non-fatal cardiovascular events were included. Spirometry included forced expiratory volume measured in units of one-second percent predicted (FEV1\%predicted) and FEV1 divided by forced vital capacity (FVC; FEV1/FVC). CT examinations were quantified for coronary artery calcium volume, pulmonary emphysema (perc15) and bronchial wall thickness (pi10). Data were analysed via a Cox proportional hazard analysis, net reclassification improvement (NRI) and C-indices.184 participants experienced a cardiovascular event during a median follow-up of 2.9 years. Age, pack-years and smoking status adjusted hazard ratios were 0.992 (95 \% confidence interval (CI) 0.985-0.999) for FEV1\%predicted, 1.000 (95\%CI 0.986-1.015) for FEV1/FVC, 1.014 (95\%CI 1.005-1.023) for perc15 per 10 HU, and 1.269 (95\%CI 1.024-1.573) for pi10 per 1 mm. The incremental C-index ( |
| وصف الملف: | application/pdf; image/pdf |
| اللغة: | English |
| تدمد: | 0938-7994 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95675923975ba261a7fbbeb124021504Test https://doi.org/10.1007/s00330-014-3384-6Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....95675923975ba261a7fbbeb124021504 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 09387994 |
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