Influence of oral contraceptive use on endothelial t-PA release in healthy premenopausal women
| العنوان: | Influence of oral contraceptive use on endothelial t-PA release in healthy premenopausal women |
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| المؤلفون: | Jared J. Greiner, Greta L. Hoetzer, Brian L. Stauffer, Yoli G. Casas, Derek T. Smith, Christopher A. DeSouza |
| المصدر: | American Journal of Physiology-Endocrinology and Metabolism. 284:E90-E95 |
| بيانات النشر: | American Physiological Society, 2003. |
| سنة النشر: | 2003 |
| مصطلحات موضوعية: | Adult, Nitroprusside, Drug, medicine.medical_specialty, Endothelium, Physiology, Vasodilator Agents, Endocrinology, Diabetes and Metabolism, medicine.medical_treatment, media_common.quotation_subject, Bradykinin, chemistry.chemical_compound, Physiology (medical), Internal medicine, Plasminogen Activator Inhibitor 1, Fibrinolysis, medicine, Humans, media_common, Dose-Response Relationship, Drug, Chemistry, Vasodilation, Forearm, Endocrinology, medicine.anatomical_structure, Contraceptive use, Premenopause, Tissue Plasminogen Activator, Female, Endothelium, Vascular, Plasminogen activator, Contraceptives, Oral |
| الوصف: | We determined the influence of oral contraceptives (OC) on the capacity of the endothelium to release tissue-type plasminogen activator (t-PA). Twenty-three healthy premenopausal women were studied: 12 nonusers and 11 users of OC. Net endothelial release rates of t-PA were calculated as the product of the arteriovenous concentration gradient and forearm plasma flow in response to intra-arterial bradykinin (BK: 12.5–50 ng · 100 ml tissue−1· min−1) and sodium nitroprusside (SNP: 1.0–4.0 μg · 100 ml tissue−1· min−1). Net release of t-PA antigen and increment in t-PA activity across the forearm to BK increased ( P < 0.01) in a dose-dependent fashion and to similar extents in the nonusers and users of OC. At the highest BK dose, net release of t-PA antigen was 64.5 ± 8.2 and 66.2 ± 15.4 ng · 100 ml tissue−1· min−1in the nonusers and users of OC, whereas the net increment in t-PA activity was 18.6 ± 3.0 and 16.0 ± 2.0 IU · 100 ml tissue−1· min−1, respectively. There was no effect of SNP on t-PA release in either group. These results indicate that endothelial t-PA release is not altered in premenopausal women who use oral contraception. |
| تدمد: | 1522-1555 0193-1849 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::951f68dda74579604ddace95c41c9664Test https://doi.org/10.1152/ajpendo.00333.2002Test |
| رقم الانضمام: | edsair.doi.dedup.....951f68dda74579604ddace95c41c9664 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15221555 01931849 |
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