Circulating inflammatory cytokines and risk of five cancers: a Mendelian randomization analysis
| العنوان: | Circulating inflammatory cytokines and risk of five cancers: a Mendelian randomization analysis |
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| المؤلفون: | PRACTICAL Consortium, Bouras, Emmanouil, Karhunen, Ville, Gill, Dipender, Huang, Jian, Haycock, Philip C, Gunter, Marc J, Johansson, Mattias, Brennan, Paul, Key, Tim, Lewis, Sarah J, Martin, Richard M, Murphy, Neil, Platz, Elizabeth A, Travis, Ruth, Yarmolinsky, James, Zuber, Verena, Martin, Paul, Katsoulis, Michail, Freisling, Heinz, Nøst, Therese Haugdahl, Schulze, Matthias B, Dossus, Laure, Hung, Rayjean J, Amos, Christopher I, Ahola-Olli, Ari, Palaniswamy, Saranya, Männikkö, Minna, Auvinen, Juha, Herzig, Karl-Heinz, Keinänen-Kiukaanniemi, Sirkka, Lehtimäki, Terho, Salomaa, Veikko, Raitakari, Olli, Salmi, Marko, Jalkanen, Sirpa, Jarvelin, Marjo-Riitta, Dehghan, Abbas, Tsilidis, Konstantinos K |
| المساهمون: | Institute for Molecular Medicine Finland, Genomics of Neurological and Neuropsychiatric Disorders, Tampere University, Department of Clinical Chemistry, Clinical Medicine |
| المصدر: | BMC Medicine Bouras, E, Karhunen, V, Gill, D, Huang, J, Haycock, P C, Gunter, M J, Johansson, M J, Brennan, P, Key, T J, Lewis, S J, Martin, R M, Murphy, N, Platz, E A, Travis, R C, Yarmolinsky, J, Zuber, V, Martin, P B, Katsoulis, M, Freisling, H, Nøst, T H, Schulze, M B, Dossus, L, Hung, R J, Amos, C I, Ahola-Olli, A V, Palaniswamy, S, Männikkö, M, Auvinen, J, Herzig, K-H, Keinänen-Kiukaanniemi, S, Lehtimäki, T, Salomaa, V, Raitakari, O, Salmi, M, Jalkanen, S, Jarvelin, M-R & Dehghan, A & Tsilidis, K K 2022, ' Circulating inflammatory cytokines and risk of five cancers : a Mendelian randomization analysis ', BMC Medicine, vol. 20, no. 1, 3 (2022) . https://doi.org/10.1186/s12916-021-02193-0Test Bouras, E, Karhunen, V, Gill, D, Huang, J, Haycock, P C, Gunter, M J, Johansson, M, Brennan, P, Key, T, Lewis, S J, Martin, R M, Murphy, N, Platz, E A, Travis, R, Yarmolinsky, J, Zuber, V, Martin, P, Katsoulis, M, Freisling, H, Nøst, T H, Schulze, M B, Dossus, L, Hung, R J, Amos, C I, Ahola-Olli, A, Palaniswamy, S, Männikkö, M, Auvinen, J, Herzig, K-H, Keinänen-Kiukaanniemi, S, Lehtimäki, T, Salomaa, V, Raitakari, O, Salmi, M, Jalkanen, S, The PRACTICAL Consortium, Jarvelin, M-R, Dehghan, A & Tsilidis, K K 2022, ' Circulating inflammatory cytokines and risk of five cancers : a Mendelian randomization analysis ', BMC Medicine, vol. 20, no. 1, 3 . https://doi.org/10.1186/s12916-021-02193-0Test BMC Medicine, Vol 20, Iss 1, Pp 1-15 (2022) |
| بيانات النشر: | BMC, 2022. |
| سنة النشر: | 2022 |
| مصطلحات موضوعية: | Male, SUSCEPTIBILITY LOCI, BIOMARKERS, Polymorphism, Single Nucleotide, OVARIAN-CANCER, 03 medical and health sciences, 0302 clinical medicine, MARKERS, Meta-Analysis as Topic, Risk Factors, Mendelian randomization, PROSTATE, INTERLEUKIN-1, Humans, Mendelian randomisation, METAANALYSIS, 030304 developmental biology, Cancer, Ovarian Neoplasms, Inflammation, 0303 health sciences, CHALLENGES, Cytokines/genetics, General Medicine, Mendelian Randomization Analysis, 3. Good health, 3121 General medicine, internal medicine and other clinical medicine, 030220 oncology & carcinogenesis, METASTASIS, Medicine, Cytokines, Female, 3111 Biomedicine, Ovarian Neoplasms/epidemiology, ICEP, LUNG, Research Article, Genome-Wide Association Study |
| الوصف: | Background Epidemiological and experimental evidence has linked chronic inflammation to cancer aetiology. It is unclear whether associations for specific inflammatory biomarkers are causal or due to bias. In order to examine whether altered genetically predicted concentration of circulating cytokines are associated with cancer development, we performed a two-sample Mendelian randomisation (MR) analysis. Methods Up to 31,112 individuals of European descent were included in genome-wide association study (GWAS) meta-analyses of 47 circulating cytokines. Single nucleotide polymorphisms (SNPs) robustly associated with the cytokines, located in or close to their coding gene (cis), were used as instrumental variables. Inverse-variance weighted MR was used as the primary analysis, and the MR assumptions were evaluated in sensitivity and colocalization analyses and a false discovery rate (FDR) correction for multiple comparisons was applied. Corresponding germline GWAS summary data for five cancer outcomes (breast, endometrial, lung, ovarian, and prostate), and their subtypes were selected from the largest cancer-specific GWASs available (cases ranging from 12,906 for endometrial to 133,384 for breast cancer). Results There was evidence of inverse associations of macrophage migration inhibitory factor with breast cancer (OR per SD = 0.88, 95% CI 0.83 to 0.94), interleukin-1 receptor antagonist with endometrial cancer (0.86, 0.80 to 0.93), interleukin-18 with lung cancer (0.87, 0.81 to 0.93), and beta-chemokine-RANTES with ovarian cancer (0.70, 0.57 to 0.85) and positive associations of monokine induced by gamma interferon with endometrial cancer (3.73, 1.86 to 7.47) and cutaneous T-cell attracting chemokine with lung cancer (1.51, 1.22 to 1.87). These associations were similar in sensitivity analyses and supported in colocalization analyses. Conclusions Our study adds to current knowledge on the role of specific inflammatory biomarker pathways in cancer aetiology. Further validation is needed to assess the potential of these cytokines as pharmacological or lifestyle targets for cancer prevention. |
| وصف الملف: | application/pdf; fulltext |
| اللغة: | English |
| تدمد: | 1741-7015 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9376887102d4f92c70f04cc9df76ae0dTest https://hdl.handle.net/11250/3033061Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....9376887102d4f92c70f04cc9df76ae0d |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 17417015 |
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