High Intensity Interval Training Ameliorates Mitochondrial Dysfunction in the Left Ventricle of Mice with Type 2 Diabetes
| العنوان: | High Intensity Interval Training Ameliorates Mitochondrial Dysfunction in the Left Ventricle of Mice with Type 2 Diabetes |
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| المؤلفون: | Simona Salerno, Paola Ceriotti, Linda H. Bergersen, Cecilie Morland, Morten A. Høydal, Tomas Stølen, Jon Storm-Mathisen, Daniele Catalucci, Fredrik Hjulstad Bækkerud |
| المصدر: | Baekkerud, F H, Salerno, S, Ceriotti, P, Morland, C, Storm-Mathisen, J, Bergersen, L H, Hoydal, M A, Catalucci, D & Stolen, T O 2019, ' High Intensity Interval Training Ameliorates Mitochondrial Dysfunction in the Left Ventricle of Mice with Type 2 Diabetes ', Cardiovascular Toxicology, vol. 19, no. 5, pp. 422-431 . https://doi.org/10.1007/s12012-019-09514-zTest |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | Male, medicine.medical_specialty, Time Factors, Strength training, Diabetic Cardiomyopathies, Alpha (ethology), Oxidative phosphorylation, Diabetic cardiomyopathy, 030204 cardiovascular system & hematology, Mitochondrion, High-Intensity Interval Training, Toxicology, Interval training, Mitochondria, Heart, Ventricular Function, Left, Exercise training, 03 medical and health sciences, Ventricular Dysfunction, Left, 0302 clinical medicine, Endurance training, Internal medicine, Medicine, Animals, Molecular Biology, business.industry, Diabetes, medicine.disease, Mice, Mutant Strains, Mitochondria, Disease Models, Animal, Endocrinology, Diabetes Mellitus, Type 2, Gene Expression Regulation, 030220 oncology & carcinogenesis, Cardiology and Cardiovascular Medicine, business, Energy Metabolism, High-intensity interval training, Signal Transduction |
| الوصف: | Both human and animal studies have shown mitochondrial and contractile dysfunction in hearts of type 2 diabetes mellitus (T2DM). Exercise training has shown positive effects on cardiac function, but its effect on the mitochondria have been insufficiently explored. The aim of this study was to assess the effect of exercise training on mitochondrial function in T2DM hearts. We divided T2DM mice (db/db) into a sedentary and an interval training group at 8 weeks of age and used heterozygote db/+ as controls. After 8 weeks of training, we evaluated mitochondrial structure and function, as well as the levels of mRNA and proteins involved in key metabolic processes from the left ventricle. db/db animals showed decreased oxidative phosphorylation capacity and fragmented mitochondria. Mitochondrial respiration showed a blunted response to Ca2+ along with reduced protein levels of the mitochondrial calcium uniporter. Exercise training ameliorated the reduced oxidative phosphorylation in complex (C) I + II, CII and CIV, but not CI or Ca2+ response. Mitochondrial fragmentation was partially restored. mRNA levels of isocitrate, succinate and oxoglutarate dehydrogenase were increased in db/db mice and normalized by exercise training. Exercise training induced an upregulation of two transcripts of peroxisome proliferator activated receptor gamma coactivator 1 alpha (PGC1α1 and PGC1α4) previously linked to endurance training adaptations and strength training adaptations, respectively. The T2DM heart showed mitochondrial dysfunction at multiple levels and exercise training ameliorated some, but not all mitochondrial dysfunctions. |
| وصف الملف: | application/pdf |
| تدمد: | 1559-0259 1530-7905 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9370ecd40d3a8c4effde6e2683869b40Test https://pubmed.ncbi.nlm.nih.gov/30927207Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....9370ecd40d3a8c4effde6e2683869b40 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15590259 15307905 |
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