Clinical and Demographic Features among Patients with Type 1 Diabetes Mellitus in Henan, China
| العنوان: | Clinical and Demographic Features among Patients with Type 1 Diabetes Mellitus in Henan, China |
|---|---|
| المؤلفون: | Xialian Li, Liguo Yang, Guangxing Yang |
| المصدر: | BMC Endocrine Disorders BMC Endocrine Disorders, Vol 21, Iss 1, Pp 1-10 (2021) |
| بيانات النشر: | Research Square Platform LLC, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Adult, Blood Glucose, Male, medicine.medical_specialty, China, Diabetic ketoacidosis, Adolescent, Epidemiology, Endocrinology, Diabetes and Metabolism, Population, Overweight, Gastroenterology, Diseases of the endocrine glands. Clinical endocrinology, Diabetic Ketoacidosis, chemistry.chemical_compound, Young Adult, Diabetes mellitus, Internal medicine, medicine, Humans, Insulin, education, Child, Aged, Retrospective Studies, Aged, 80 and over, Glycated Hemoglobin, Type 1 diabetes, education.field_of_study, Chinese, business.industry, Glutamate Decarboxylase, Research, General Medicine, Middle Aged, RC648-665, medicine.disease, Diabetes Mellitus, Type 1, chemistry, Child, Preschool, Female, Glycated hemoglobin, medicine.symptom, business, Body mass index, Dyslipidemia, Biomarkers |
| الوصف: | Background The hallmark of type 1 diabetes (T1D) is an absolute lack of insulin. However, many studies showed a tendency to heterogeneity in TID. We aimed to investigate the demographic and clinical characteristics in T1D and the differences in young-onset and adult-onset patients. Methods This retrospective study was conducted among 1943 patients with clinically diagnosed T1D. Medical records on patients’ demographics, anthropometric measurements, and clinical manifestation were collected. According to the age at onset, the newly diagnosed patients were divided into the young-onset group ( Results The median age of patients at disease onset was 22 years. The median duration of patients was 3 years. The overall median glycated hemoglobin (HbA1c) value was 10.3 % [89(mmol/mol)]. The prevalence of diabetic retinopathy was 25.1 %. The overall rate of DKA at onset in the new-onset patients was 59.6 %. The frequency of overall dyslipidemia was 37.8 %. The most frequent dyslipidemia was low high-density lipoprotein-cholesterol (HDL) (29 %). The proportion of patients with anti-glutamic acid decarboxylase (GADA), insulin antibody (IAA) and islet cell antibody (ICA) were 28.1 %, 6.4 % and 21.6 %, respectively. The mean HbA1c showed a downward trend with age. Increasing or decreasing trends of overweight and obesity in this population during the period 2012 to 2018 was not found. Compared with young-onset T1D, adult-onset patients comprised better islet function (FCP: 0.4 vs. 0.3 ng/ml, P P P P = 0.006), higher proportion of obesity or overweight (24.6 % vs. 9.5 %, P = 0.002), higher frequency of GADA (33.7 % vs. 23.3 %, P = 0.025), and lower frequency of diabetic ketoacidosis at disease onset (64.5 % vs. 43.5 %, P Conclusions This population was characterized by poor overall blood glucose control, high prevalence of DKA, dyslipidemia and diabetic retinopathy, and low prevalence of islet-related antibodies, and overweight or obesity. Adult-onset patients with T1D were not uncommon and had better clinical manifestations than young-onset patients. Any findings related to body mass index (BMI) and autoantibodies should be considered strictly exploratory due to excessive missing data. |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::935124236fdc6fbe062120268ab5750cTest https://doi.org/10.21203/rs.3.rs-144376/v1Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....935124236fdc6fbe062120268ab5750c |
| قاعدة البيانات: | OpenAIRE |
| الوصف غير متاح. |