Loss of DNA-mismatch repair gene expression in oral melanomas
| العنوان: | Loss of DNA-mismatch repair gene expression in oral melanomas |
|---|---|
| المؤلفون: | Johannes Franz Hönig, Monika Korabiowska, Ulrich Brinck, Droese M, Ruschenburg I, J Stachura |
| المصدر: | Oncology Reports. |
| بيانات النشر: | Spandidos Publications, 1999. |
| سنة النشر: | 1999 |
| مصطلحات موضوعية: | Male, Cancer Research, Pathology, DNA Repair, Base Pair Mismatch, Gene Expression, Malignant transformation, 0302 clinical medicine, PMS2, Melanoma, Mismatch Repair Endonuclease PMS2, Adenosine Triphosphatases, Aged, 80 and over, 0303 health sciences, Nuclear Proteins, General Medicine, Middle Aged, Cell cycle, Neoplasm Proteins, DNA-Binding Proteins, MutS Homolog 2 Protein, Oncology, 030220 oncology & carcinogenesis, Female, Mouth Neoplasms, DNA mismatch repair, MutL Protein Homolog 1, Adult, congenital, hereditary, and neonatal diseases and abnormalities, medicine.medical_specialty, DNA Ligases, Biology, MLH1, 03 medical and health sciences, Proto-Oncogene Proteins, medicine, Humans, Gene, Adaptor Proteins, Signal Transducing, Aged, 030304 developmental biology, Ploidies, medicine.disease, digestive system diseases, DNA Repair Enzymes, MutL Proteins, MSH2, Cancer research, Carrier Proteins |
| الوصف: | The defect of DNA mismatch repair is postulated to be responsible for malignant transformation in many types to be responsible for malignant transformation in many types of tumours. The main aim of this study was to evaluate the expression of DNA mismatch repair proteins in 29 cases of oral melanomas and to relate this to the ploidy status of the lesions. MLH1 expression was found in 4/29, MSH2 in 6/29, PMS2 in 2/29 and PMS1 in 0/29 cases investigated. The range of positively stained cells did not exceed 50% with MSH2, and PMS2, or 5% with MLH1. Loss of the DNA mismatch repair gene expression correlated with high aneuploidy ratio, observed in totally negative cases. |
| تدمد: | 1791-2431 1021-335X |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9299090ce99a53bcf17214194aa70e2bTest https://doi.org/10.3892/or.6.4.921Test |
| رقم الانضمام: | edsair.doi.dedup.....9299090ce99a53bcf17214194aa70e2b |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 17912431 1021335X |
|---|