Omega-3 polyunsaturated fatty acid supplementation versus placebo on vascular health, glycaemic control, and metabolic parameters in people with type 1 diabetes: a randomised controlled preliminary trial
| العنوان: | Omega-3 polyunsaturated fatty acid supplementation versus placebo on vascular health, glycaemic control, and metabolic parameters in people with type 1 diabetes: a randomised controlled preliminary trial |
|---|---|
| المؤلفون: | Mel Holmes, Christine Boesch, Oliver J. Price, Georgia Mappa, Nicolas M. Orsi, Gareth Dunseath, Matthew Campbell, Rachel Churm, Lauren L. O’Mahoney, Antonios Stavropoulos-Kalinoglou, Karen M. Birch, Ramzi A. Ajjan |
| المصدر: | Cardiovascular Diabetology, Vol 19, Iss 1, Pp 1-10 (2020) Cardiovascular Diabetology |
| بيانات النشر: | BMC, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Blood Glucose, Male, lcsh:Diseases of the circulatory (Cardiovascular) system, Time Factors, Endocrinology, Diabetes and Metabolism, Blood Pressure, Gastroenterology, law.invention, Randomized controlled trial, law, Glycaemic control, Glucose homeostasis, Original Investigation, chemistry.chemical_classification, Omega-3 polyunsaturated fatty acids, Middle Aged, Vasodilation, Treatment Outcome, Type 1 diabetes, Postprandial, England, Female, Inflammation Mediators, Cardiology and Cardiovascular Medicine, Polyunsaturated fatty acid, Adult, medicine.medical_specialty, Glycemic Control, Placebo, Young Adult, Double-Blind Method, Internal medicine, Diabetes mellitus, Fatty Acids, Omega-3, medicine, Humans, Hypoglycemic Agents, Angiology, Glycated Hemoglobin, Vascular health, business.industry, Hemodynamics, medicine.disease, Diabetes Mellitus, Type 1, chemistry, lcsh:RC666-701, Dietary Supplements, business, Biomarkers |
| الوصف: | Background The role of omega-3 polyunsaturated fatty acids (n-3PUFA), and the potential impact of n-3PUFA supplementation, in the treatment and management of type 1 diabetes (T1D) remains unclear and controversial. Therefore, this study aimed to examine the efficacy of daily high-dose-bolus n-3PUFA supplementation on vascular health, glycaemic control, and metabolic parameters in subjects with T1D. Methods Twenty-seven adults with T1D were recruited to a 6-month randomised, double-blind, placebo-controlled trial. Subjects received either 3.3 g/day of encapsulated n-3PUFA or encapsulated 3.0 g/day corn oil placebo (PLA) for 6-months, with follow-up at 9-months after 3-month washout. Erythrocyte fatty acid composition was determined via gas chromatography. Endpoints included inflammation-associated endothelial biomarkers (vascular cell adhesion molecule-1 [VCAM-1], intercellular adhesion molecule-1 [ICAM-1], E-selectin, P-selectin, pentraxin-3, vascular endothelial growth factor [VEGF]), and their mediator tumor necrosis factor alpha [TNFα] analysed via immunoassay, vascular structure (carotid intima-media thickness [CIMT]) and function (brachial artery flow mediated dilation [FMD]) determined via ultrasound technique, blood pressure, glycosylated haemoglobin (HbA1c), fasting plasma glucose (FPG), and postprandial metabolism. Results Twenty subjects completed the trial in full. In the n-3PUFA group, the mean ± SD baseline n-3PUFA index of 4.93 ± 0.94% increased to 7.67 ± 1.86% (P P P P > 0.05). Conclusions This study indicates that daily high-dose-bolus of n-3PUFA supplementation for 6-months does not improve vascular health, glucose homeostasis, or metabolic parameters in subjects with T1D. The findings from this preliminary RCT do not support the use of therapeutic n-3PUFA supplementation in the treatment and management of T1D and its associated complications. Trial Registration ISRCTN, ISRCTN40811115. Registered 27 June 2017, http://www.isrctn.com/ISRCTN40811115Test. |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 4081-1115 1475-2840 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::925df1666e9b8f2720e4b458144c7ef2Test http://sure.sunderland.ac.uk/id/eprint/13285/1/13285.pdfTest |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....925df1666e9b8f2720e4b458144c7ef2 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 40811115 14752840 |
|---|