Type 1 diabetes genetic risk score is discriminative of diabetes in non-Europeans: evidence from a study in India
| العنوان: | Type 1 diabetes genetic risk score is discriminative of diabetes in non-Europeans: evidence from a study in India |
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| المؤلفون: | Seema Bhaskar, Kashyap A. Patel, Chittaranjan S. Yajnik, Michael N. Weedon, Seth A. Sharp, Kalpana S. Jog, Richard A. Oram, James W. Harrison, Giriraj R. Chandak, Divya Sri Priyanka Tallapragada, Alma Baptist |
| المصدر: | Scientific Reports Scientific Reports, Vol 10, Iss 1, Pp 1-7 (2020) |
| بيانات النشر: | Springer Science and Business Media LLC, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Male, 0301 basic medicine, endocrine system diseases, lcsh:Medicine, Type 2 diabetes, 0302 clinical medicine, Discriminative model, immune system diseases, Genetics research, Medicine, Young adult, lcsh:Science, Child, education.field_of_study, Multidisciplinary, Molecular medicine, Middle Aged, Type 1 diabetes, Female, Adult, endocrine system, Adolescent, Population, India, 030209 endocrinology & metabolism, Single-nucleotide polymorphism, Polymorphism, Single Nucleotide, Article, 03 medical and health sciences, Asian People, Diabetes mellitus, Humans, SNP, Genetic Predisposition to Disease, education, Alleles, business.industry, lcsh:R, fungi, nutritional and metabolic diseases, medicine.disease, Diabetes Mellitus, Type 1, 030104 developmental biology, Risk factors, Diabetes Mellitus, Type 2, Case-Control Studies, lcsh:Q, business, Demography |
| الوصف: | Type 1 diabetes (T1D) is a significant problem in Indians and misclassification of T1D and type 2 diabetes (T2D) is a particular problem in young adults in this population due to the high prevalence of early onset T2D at lower BMI. We have previously shown a genetic risk score (GRS) can be used to discriminate T1D from T2D in Europeans. We aimed to test the ability of a T1D GRS to discriminate T1D from T2D and controls in Indians. We studied subjects from Pune, India of Indo-European ancestry; T1D (n = 262 clinically defined, 200 autoantibody positive), T2D (n = 345) and controls (n = 324). We used the 9 SNP T1D GRS generated in Europeans and assessed its ability to discriminate T1D from T2D and controls in Indians. We compared Indians with Europeans from the Wellcome Trust Case Control Consortium study; T1D (n = 1963), T2D (n = 1924) and controls (n = 2938). The T1D GRS was discriminative of T1D from T2D in Indians but slightly less than in Europeans (ROC AUC 0.84 v 0.87, p |
| تدمد: | 2045-2322 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91acd61b75dfc505d45621488b7c127bTest https://doi.org/10.1038/s41598-020-65317-1Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....91acd61b75dfc505d45621488b7c127b |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20452322 |
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