Serum levels of soluble programmed cell death protein 1 and soluble programmed cell death protein ligand 2 are increased in systemic lupus erythematosus and associated with the disease activity
| العنوان: | Serum levels of soluble programmed cell death protein 1 and soluble programmed cell death protein ligand 2 are increased in systemic lupus erythematosus and associated with the disease activity |
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| المؤلفون: | Hidenaga Kawasumi, Masayoshi Harigai, Yashushi Kawaguchi, Shinya Hirahara, Yasuhiro Katsumata |
| المصدر: | Lupus. 29:686-696 |
| بيانات النشر: | SAGE Publications, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Adult, Male, 0301 basic medicine, Programmed cell death, Adolescent, Enzyme-Linked Immunosorbent Assay, B7-H1 Antigen, Disease activity, Young Adult, 03 medical and health sciences, 0302 clinical medicine, Rheumatology, Programmed cell death 1, mental disorders, Humans, Lupus Erythematosus, Systemic, Medicine, Aged, Retrospective Studies, 030203 arthritis & rheumatology, biology, business.industry, Middle Aged, Programmed Cell Death 1 Ligand 2 Protein, 030104 developmental biology, Immunology, Disease Progression, biology.protein, Female, business, Biomarkers, Protein ligand |
| الوصف: | Objective Programmed cell death protein 1 (PD-1) pathway plays important roles in systemic lupus erythematosus (SLE). We aimed to elucidate the association of serum soluble PD-1 (sPD-1) and related molecules with SLE and to explore their usefulness as biomarkers. Methods We retrospectively measured the serum levels of sPD-1, soluble PD-ligand 1 (sPD-L1), soluble PD-ligand 2 (sPD-L2) and interleukin (IL)-21 by ELISA in SLE patients, systemic sclerosis patients and healthy controls. Repeat sera samples were also obtained post treatment. Results The serum levels of sPD-1 and sPD-L2 in SLE patients with high disease activity were significantly higher than those in SLE patients with low disease activity, systemic sclerosis patients and healthy controls ( n = 58, 15, 20 and 21, respectively; p Conclusion The present study demonstrated the association of serum sPD-1 and sPD-L2 with SLE and suggests their usefulness as disease activity biomarkers for SLE. |
| تدمد: | 1477-0962 0961-2033 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::917cd57976a3fdceeef90e8f3dbede39Test https://doi.org/10.1177/0961203320916517Test |
| حقوق: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....917cd57976a3fdceeef90e8f3dbede39 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14770962 09612033 |
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