Kelch-like protein 3 in human disease and therapy
| العنوان: | Kelch-like protein 3 in human disease and therapy |
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| المؤلفون: | Yan Lin, Qian Li, Xiaofeng Jin |
| المصدر: | Molecular Biology Reports. 49:9813-9824 |
| بيانات النشر: | Springer Science and Business Media LLC, 2022. |
| سنة النشر: | 2022 |
| مصطلحات موضوعية: | Ubiquitin, Pseudohypoaldosteronism, Microfilament Proteins, Genetics, Humans, General Medicine, Protein Serine-Threonine Kinases, Carrier Proteins, Cullin Proteins, Molecular Biology, Adaptor Proteins, Signal Transducing |
| الوصف: | Kelch-like protein 3 (KLHL3) is a substrate adaptor of Cullin3-RING ubiquitin ligase (CRL3), and KLHL3-CUL3 complex plays a vital role in the ubiquitination of specific substrates. Mutations and abnormal post-translational modifications of KLHL3-CUL3 affect substrate ubiquitination and may related to the pathogenesis of Gordon syndrome (GS), Primary Hyperparathyroidism (PHPT), Diabetes Mellitus (DM), Congenital Heart Disease (CHD), Pre-eclampsia (PE) and even cancers. Therefore, it is essential to understand the function and molecular mechanisms of KLHL3-CUL3 for the treatment of related diseases. In this review, we summary the structure and function of KLHL3-CUL3, the effect of KLHL3-CUL3 mutations and aberrant modifications in GS, PHPT, DM, CHD and PE. Moreover, we noted a possible role of KLHL3-CUL3 in carcinogenesis and provided ideas for targeting KLHL3-CUL3 for related disease treatment. |
| تدمد: | 1573-4978 0301-4851 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91471cbf6b68e8df3678e8404779cec3Test https://doi.org/10.1007/s11033-022-07487-xTest |
| حقوق: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....91471cbf6b68e8df3678e8404779cec3 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15734978 03014851 |
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