Restored expression levels of TET1 decrease the proliferation and migration of renal carcinoma cells
| العنوان: | Restored expression levels of TET1 decrease the proliferation and migration of renal carcinoma cells |
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| المؤلفون: | Min Fan, Xiaozhou He, Xianlin Xu |
| المصدر: | Molecular Medicine Reports |
| بيانات النشر: | Spandidos Publications, 2015. |
| سنة النشر: | 2015 |
| مصطلحات موضوعية: | Adult, Male, Cancer Research, Pathology, medicine.medical_specialty, Cell Survival, proliferation, Cell, Apoptosis, Biology, Biochemistry, Mixed Function Oxygenases, Cell Movement, Proto-Oncogene Proteins, Genetics, medicine, Carcinoma, Humans, Carcinoma, Renal Cell, Molecular Biology, Cell Proliferation, ten-eleven translocation methylcytosine dioxygenase 1, cell apoptosis, Oncogene, Cancer, Articles, renal carcinoma, Cell cycle, Prognosis, invasion, medicine.disease, Molecular medicine, DNA-Binding Proteins, HEK293 Cells, medicine.anatomical_structure, Gene Expression Regulation, Oncology, Molecular Medicine, Female, Kidney cancer |
| الوصف: | Renal carcinoma is the most common type of kidney cancer in adults and is responsible for ~90–95% of the cases of kidney cancer. Ten-eleven translocation methylcytosine dioxygenase 1 (TET1) is a member of the TET family of enzymes, and is expressed at low levels in multiple malignancies. In the present study, a series of experiments were designed and performed to investigate whether the expression of TET1 is clinically correlated with clinical outcomes in renal carcinoma, and to examine the associations between TET1 expression level and the proliferation and migration in renal carcinoma cells. As a result, TET1 was observed to exhibit markedly low expression levels in 54 tumor tissue samples from 54 patients with renal carcinoma. Furthermore, statistical analysis revealed a clinical correlation between low expression levels of TET1 and the prognosis of patients with renal carcinoma. When TET1 was overexpressed in renal carcinoma cells, the viability and invasive abilities of the cells were decreased, and the rate of apoptosis was increased. In conclusion, the results demonstrated that TET1 is involved in tumor inhibition in renal carcinoma by promoting cell apoptosis and inhibiting cell proliferation and invasion, which may be exploited as a novel therapeutic target in the treatment of renal carcinoma. |
| تدمد: | 1791-3004 1791-2997 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91138dc62cced48be3c4583f70e0e861Test https://doi.org/10.3892/mmr.2015.4058Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....91138dc62cced48be3c4583f70e0e861 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 17913004 17912997 |
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