Pathological evaluation of tumor grade for salivary adenoid cystic carcinoma: A proposal of an objective grading system
| العنوان: | Pathological evaluation of tumor grade for salivary adenoid cystic carcinoma: A proposal of an objective grading system |
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| المؤلفون: | Makoto Urano, Toru Nagao, Kazuo Sakurai, Ryo Kawata, Kenji Okami, Kimihide Kusafuka, Ken-ichi Nibu, Tetsuro Onitsuka, Hiroshi Inagaki, Toshitaka Nagao, Ken Ichi Taguchi, Kiyoaki Tsukahara, Kaori Ueda, Nobuhiro Hanai, Naruhiko Morita, Yasushi Fujimoto, Daisuke Kawakita, Satoshi Kano, Takayuki Murase, Yuichiro Tada, Naohito Hato, Masato Nakaguro, Hidetaka Yamamoto, Naoki Otsuki |
| المصدر: | Cancer Science |
| بيانات النشر: | Wiley, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Adult, Male, 0301 basic medicine, Cancer Research, medicine.medical_specialty, interobserver variability, pathological grading system, Adenoid cystic carcinoma, salivary gland, Disease-Free Survival, Salivary Glands, Young Adult, 03 medical and health sciences, Tumor grade, 0302 clinical medicine, Cohen's kappa, Pathology, Overall survival, Humans, Medicine, Cutoff, adenoid cystic carcinoma, Grading (education), Pathological, Aged, Retrospective Studies, Aged, 80 and over, business.industry, Hazard ratio, Reproducibility of Results, Original Articles, General Medicine, Middle Aged, Prognosis, Salivary Gland Neoplasms, medicine.disease, Carcinoma, Adenoid Cystic, 030104 developmental biology, Oncology, 030220 oncology & carcinogenesis, Female, Original Article, Radiology, Neoplasm Grading, business |
| الوصف: | Three pathological grading systems advocated by Perzin/Szanto, Spiro, and van Weert are currently used for adenoid cystic carcinoma (AdCC). In these systems, the amount or presence of the solid tumor component in AdCC specimens is an important index. However, the “solid tumor component” has not been well defined. Salivary AdCC cases (N = 195) were collected after a central pathology review. We introduced a novel criterion for solid tumor component, minAmax (minor axis maximum). The largest solid tumor nest in each AdCC case was histologically screened, the maximum oval fitting the solid nest was estimated, and the length of the minor axis of the oval (minAmax) was measured. The prognostic cutoff for the minAmax was determined using training and validation cohorts. All cases were evaluated for the four grading systems, and their prognostic impact and interobserver variability were examined. The cutoff value for the minAmax was set at 0.20 mm. Multivariate prognostic analyses showed the minAmax and van Weert systems to be independent prognostic tools for overall, disease‐free, and distant metastasis‐free survival while the Perzin/Szanto and Spiro systems were selected for overall survival but not for disease‐free or distant metastasis‐free survival. The highest hazard ratio for overall survival (11.9) was obtained with the minAmax system. The reproducibility of the minAmax system (kappa coefficient of 0.81) was scored as very good while those of the other three systems were scored as moderate. In conclusion, the minAmax is a simple, objective, and highly reproducible grading system useful for prognostic stratification for salivary AdCC. The amount or presence of the solid tumor component is an important index for histopathological grading of adenoid cystic carcinoma. However, the “solid tumor component” has not been well defined. We introduced a novel objective criterion for solid tumor component, minAmax (minor axis maximum), and showed that the minAmax is a simple, objective, and highly reproducible grading system useful for prognostic stratification for salivary adenoid cystic carcinoma. |
| تدمد: | 1349-7006 1347-9032 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90bff336af9bba9a180b3e52e07f3a60Test https://doi.org/10.1111/cas.14790Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....90bff336af9bba9a180b3e52e07f3a60 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 13497006 13479032 |
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