An update on the use of immunoglobulins as treatment for myasthenia gravis
| العنوان: | An update on the use of immunoglobulins as treatment for myasthenia gravis |
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| المؤلفون: | Monica, Alcantara, Carolina, Barnett, Hans, Katzberg, Vera, Bril |
| المصدر: | Expert Review of Clinical Immunology. 18:703-715 |
| بيانات النشر: | Informa UK Limited, 2022. |
| سنة النشر: | 2022 |
| مصطلحات موضوعية: | Chronic Disease, Myasthenia Gravis, Immunology, Quality of Life, Humans, Immunoglobulins, Immunoglobulins, Intravenous, Immunology and Allergy, Antibodies |
| الوصف: | Myasthenia gravis (MG) is an antibody mediated disease where pathogenic antibodies interact with the acetylcholine receptor or other proteins at the post-synaptic neuromuscular junction. There is growing evidence that immunoglobulin infusions are beneficial for clinical exacerbations and chronic refractory disease and may be an option for patients unresponsive to conventional immunosuppressive therapies.We performed an extensive literature review, looking for evidence on the use of immunoglobulins for the treatment of MG, by conducting a search in MEDLINE (1946 to present), EMBASE (1947 to present) and Clinicaltrials.gov. We have included studies on the use of intravenous immunoglobulins (IVIG) and subcutaneous immunoglobulins (SCIG) for acute deterioration and chronic disease.The use of IVIG in MG provides an option for rapid improvement in critical deterioration, being preferred over more invasive and less available therapies such as plasmapheresis. For refractory MG, the addition of IVIG can improve a patient's status and reduce the dosage of immunosuppressive medications. The alternative of SCIG is also effective and has advantages of infusion time flexibility, fewer side-effects, and patient independence. The safety and efficacy of both interventions, patient preferences and quality of life may direct therapeutic choices in the future. |
| تدمد: | 1744-8409 1744-666X |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9098d6766d6a4cbdd3afa54c9dffba1dTest https://doi.org/10.1080/1744666x.2022.2084074Test |
| رقم الانضمام: | edsair.doi.dedup.....9098d6766d6a4cbdd3afa54c9dffba1d |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 17448409 1744666X |
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