Genome-wide association study on coronary artery disease in type 1 diabetes suggests beta-defensin 127 as a risk locus
| العنوان: | Genome-wide association study on coronary artery disease in type 1 diabetes suggests beta-defensin 127 as a risk locus |
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| المؤلفون: | A. Antikainen, Per-Henrik Groop, Tarunveer S. Ahluwalia, Valma Harjutsalo, Alexander P. Maxwell, Samy Hadjadj, Daniel Gordin, David-Alexandre Trégouët, Anna Syreeni, Romain Charmet, Carol Forsblom, Niina Sandholm, Erkka Valo, Peter Rossing, Amy Jayne McKnight |
| المساهمون: | University of Helsinki, Clinicum, University of Helsinki, Medicum, University of Helsinki, HUS Abdominal Center, University of Helsinki, Research Programs Unit, Bordeaux population health (BPH), Université de Bordeaux (UB)-Institut de Santé Publique, d'Épidémiologie et de Développement (ISPED)-Institut National de la Santé et de la Recherche Médicale (INSERM), Clinicum, HUS Abdominal Center, Nefrologian yksikkö, University of Helsinki, Helsinki University Hospital Area, CAMM - Research Program for Clinical and Molecular Metabolism, Faculty of Medicine, Medicum, Research Programs Unit, Department of Medicine, Per Henrik Groop / Principal Investigator |
| المصدر: | Antikainen, A A V, Sandholm, N, Trégouët, D A, Charmet, R, McKnight, A J, Ahluwalia, T S, Syreeni, A, Valo, E, Forsblom, C, Gordin, D, Harjutsalo, V, Hadjadj, S, Maxwell, A P, Rossing, P & Groop, P H 2021, ' Genome-wide association study on coronary artery disease in type 1 diabetes suggests beta-defensin 127 as a risk locus ', Cardiovascular Research, vol. 117, no. 2, pp. 600-612 . https://doi.org/10.1093/cvr/cvaa045Test Cardiovascular Research Cardiovascular Research, Oxford University Press (OUP), 2021, 117 (2), pp.600-612. ⟨10.1093/cvr/cvaa045⟩ Cardiovasc Res |
| بيانات النشر: | Oxford University Press (OUP), 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Male, 0301 basic medicine, beta-Defensins, Physiology, Genome-wide association study, Coronary Artery Disease, Disease, 030204 cardiovascular system & hematology, Bioinformatics, Coronary artery disease, 0302 clinical medicine, Risk Factors, Medicine, Registries, Promoter Regions, Genetic, Finland, education.field_of_study, Middle Aged, Cardiovascular disease, 3. Good health, Phenotype, Type 1 diabetes, Female, RNA, Long Noncoding, TYPE 1 DIABETES, Cardiology and Cardiovascular Medicine, Adult, GENETICS, education, Population, CARDIOVASCULAR DISEASE, 3121 Internal medicine, Polymorphism, Single Nucleotide, Risk Assessment, 03 medical and health sciences, Physiology (medical), Diabetes mellitus, Genetics, Humans, Genetic Predisposition to Disease, Aged, Genetic association, business.industry, Original Articles, medicine.disease, Diabetes Mellitus, Type 1, 030104 developmental biology, Intima-media thickness, Genetic Loci, Case-Control Studies, 3121 General medicine, internal medicine and other clinical medicine, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, business, Genome-Wide Association Study |
| الوصف: | AIMS: Diabetes is a known risk factor for coronary artery disease. There is accumulating evidence that coronary artery disease pathogenesis differs for individuals with type 1 diabetes. However, the genetic background has not been extensively studied. We aimed to discover genetic loci increasing coronary artery disease susceptibility especially in type 1 diabetes, to examine the function of these discoveries and to study the role of the known risk loci in type 1 diabetes. METHODS AND RESULTS: We performed the largest genome-wide association study to date for coronary artery disease in type 1 diabetes, comprising 4869 individuals with type 1 diabetes (cases/controls: 941/3928). Two loci reached genome-wide significance, rs1970112 in CDKN2B-AS1 (OR = 1.32, p=1.50 x 10-8), and rs6055069 on DEFB127 promoter (OR = 4.17, p=2.35 x 10-9), with consistent results in survival analysis. The CDKN2B-AS1 variant replicated (p=0.04) when adjusted for diabetic kidney disease in three additional type 1 diabetes cohorts (cases/controls: 434/3123). Furthermore, we explored the function of the lead discoveries with a cardio-phenome-wide analysis. Among the eight suggestive loci (p |
| وصف الملف: | application/pdf |
| تدمد: | 1755-3245 0008-6363 7096-2766 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90707e16ee86e9e85d8ed2e8fdd3a1b9Test https://doi.org/10.1093/cvr/cvaa045Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....90707e16ee86e9e85d8ed2e8fdd3a1b9 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 17553245 00086363 70962766 |
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