The Value of Anti-Desmoglein Enzyme-Linked Immunosorbent Assay in the Immunological Follow-Up of Pemphigus
| العنوان: | The Value of Anti-Desmoglein Enzyme-Linked Immunosorbent Assay in the Immunological Follow-Up of Pemphigus |
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| المؤلفون: | Nicolas Ortonne, Pierre Wolkenstein, Saskia Ingen-Housz-Oro, N. Bellon, Chantal Andre, Olivier Chosidow, Emilie Sbidian |
| المصدر: | Dermatology. 229:256-262 |
| بيانات النشر: | S. Karger AG, 2014. |
| سنة النشر: | 2014 |
| مصطلحات موضوعية: | Adult, Male, Databases, Factual, Enzyme-Linked Immunosorbent Assay, Dermatology, Sensitivity and Specificity, Severity of Illness Index, Desmoglein, Statistics, Nonparametric, Young Adult, stomatognathic system, Humans, Medicine, Fluorescent Antibody Technique, Indirect, Aged, Monitoring, Physiologic, Retrospective Studies, chemistry.chemical_classification, Desmoglein 3, integumentary system, business.industry, Desmoglein 1, Middle Aged, medicine.disease, Pemphigus, Enzyme, chemistry, Fluorescent Antibody Technique, Direct, Immunology, Disease Progression, Female, France, business, Value (mathematics), Follow-Up Studies |
| الوصف: | Background: The value of anti-desmoglein 1 and 3 (Dsg1, Dsg3) enzyme-linked immunosorbent assay (ELISA) is controversial in the follow-up of pemphigus. Objective: To evaluate anti-desmoglein ELISA (Dsg ELISA) in the follow-up of pemphigus and compare ELISA with direct and indirect immunofluorescence in complete remission (CR). Methods: We performed a retrospective monocenter study of patients with pemphigus and consecutive sera samples collected at baseline (M0), 12 months (M12) and 24 or 36 months after M0 (M24/36). Tests were compared in CR and in active disease. Direct immunofluorescence and circulating autoantibodies were compared for patients with stable CR. Results: We included 36 patients. At M12, ELISA values did not differ between CR and active disease. At M24/36, Dsg3 but not Dsg1 ELISA values were lower in CR (p = 0.07). For 5/8 patients with stable CR, direct immunofluorescence and ELISA findings remained positive. Conclusion: In routine practice, Dsg ELISA seems to be of little interest for immunological follow-up of pemphigus. |
| تدمد: | 1421-9832 1018-8665 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9025afa7f1cc5754b5c1a1fb65980aa8Test https://doi.org/10.1159/000365079Test |
| حقوق: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....9025afa7f1cc5754b5c1a1fb65980aa8 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14219832 10188665 |
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