Vascular Endothelial Growth Factor Level as a Prognostic Determinant of Small Cell Lung Cancer in Japanese Patients
| العنوان: | Vascular Endothelial Growth Factor Level as a Prognostic Determinant of Small Cell Lung Cancer in Japanese Patients |
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| المؤلفون: | Shingo Takanashi, Ken Okumura, Mika Kumagai, Akihito Hayashi, Takeshi Morimoto, Yukihiro Hasegawa, Koichi Okudera |
| المصدر: | Internal Medicine. 44:26-34 |
| بيانات النشر: | Japanese Society of Internal Medicine, 2005. |
| سنة النشر: | 2005 |
| مصطلحات موضوعية: | Male, Vascular Endothelial Growth Factor A, medicine.medical_specialty, Pathology, Lung Neoplasms, Enolase, Sensitivity and Specificity, Gastroenterology, chemistry.chemical_compound, Japan, Internal medicine, Lactate dehydrogenase, Internal Medicine, Carcinoma, Humans, Medicine, Clinical significance, Platelet, Carcinoma, Small Cell, Survival analysis, Aged, L-Lactate Dehydrogenase, Platelet Count, business.industry, General Medicine, Middle Aged, Prognosis, medicine.disease, Immunohistochemistry, Survival Analysis, respiratory tract diseases, Vascular endothelial growth factor, chemistry, Multivariate Analysis, Disease Progression, Female, business |
| الوصف: | Objective To clarify the clinical significance of vascular endothelial growth factor (VEGF) in Japanese patients with small cell lung cancer (SCLC).Materials and Methods We measured serum VEGF levels using an enzyme-linked immunosorbent assay in 45 patients with SCLC before treatment and in 38 patients with benign pulmonary disease and in 32 healthy subjects (71 non-malignant subjects). VEGF immunostaining was performed in tissue biopsies obtained from 23 SCLC patients during bronchoscopic examination.Results Median serum VEGF level was 332 pg/ml in patients with SCLC and 160 pg/ml in non-malignant subjects, respectively. The 95% cut-off level to exclude non-malignant subjects was 500 pg/ml. An elevated VEGF level (>500 pg/ml) was found more frequently in patients with extensive disease of SCLC than in those with the limited disease (p |
| تدمد: | 1349-7235 0918-2918 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8fd4aa9d7e150e7b98561a613b94dd8fTest https://doi.org/10.2169/internalmedicine.44.26Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....8fd4aa9d7e150e7b98561a613b94dd8f |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 13497235 09182918 |
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