Impact of clinical and subclinical coronary artery disease as assessed by coronary artery calcium in COVID-19
| العنوان: | Impact of clinical and subclinical coronary artery disease as assessed by coronary artery calcium in COVID-19 |
|---|---|
| المؤلفون: | Arif A. Khokhar, Alberto Pacielli, Francesco Ponticelli, Marco Toselli, Gianmarco Iannopollo, Alberto Monello, Davide Ippolito, Antonio Colombo, Alessandro Sticchi, Antonio Esposito, Anna Palmisano, Luigi Vignali, Gianluca Campo, Pietro Andrea Bonaffini, Valeria Nicoletti, Caterina Chiara De Carlini, Daniele Andreini, Claudia Costa, Riccardo Leone, Giorgio Benatti, Giacomo Bellani, Marco Loffi, Andrea Biagi, Carlo Tacchetti, Fabio Anastasio, Elisa Scarnecchia, Chiara Gnasso, Alessandra Scoccia, Stefano Maggiolini, Gian Battista Danzi, Roberto Ferrari, Francesca Besana, Gianluigi Patelli, Claudio Rapezzi, Mario Iannaccone, Davide Vignale, Michele Senni, Gianluca Pontone, Guglielmo Gallone, Francesco Giannini, Gianni Casella, Alberto Cereda, Paolo Giacomo Vaudano |
| المساهمون: | Scoccia, A, Gallone, G, Cereda, A, Palmisano, A, Vignale, D, Leone, R, Nicoletti, V, Gnasso, C, Monello, A, Khokhar, A, Sticchi, A, Biagi, A, Tacchetti, C, Campo, G, Rapezzi, C, Ponticelli, F, Danzi, G, Loffi, M, Pontone, G, Andreini, D, Casella, G, Iannopollo, G, Ippolito, D, Bellani, G, Patelli, G, Besana, F, Costa, C, Vignali, L, Benatti, G, Iannaccone, M, Vaudano, P, Pacielli, A, De Carlini, C, Maggiolini, S, Bonaffini, P, Senni, M, Scarnecchia, E, Anastasio, F, Colombo, A, Ferrari, R, Esposito, A, Giannini, F, Toselli, M, Scoccia, A., Gallone, G., Cereda, A., Palmisano, A., Vignale, D., Leone, R., Nicoletti, V., Gnasso, C., Monello, A., Khokhar, A., Sticchi, A., Biagi, A., Tacchetti, C., Campo, G., Rapezzi, C., Ponticelli, F., Danzi, G. B., Loffi, M., Pontone, G., Andreini, D., Casella, G., Iannopollo, G., Ippolito, D., Bellani, G., Patelli, G., Besana, F., Costa, C., Vignali, L., Benatti, G., Iannaccone, M., Vaudano, P. G., Pacielli, A., De Carlini, C. C., Maggiolini, S., Bonaffini, P. A., Senni, M., Scarnecchia, E., Anastasio, F., Colombo, A., Ferrari, R., Esposito, A., Giannini, F., Toselli, M. |
| المصدر: | Atherosclerosis |
| بيانات النشر: | Elsevier Ireland Ltd, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | 0301 basic medicine, Male, medicine.medical_specialty, coronary artery calcifications, Coronary Artery Disease, Coronary artery calcification, 030204 cardiovascular system & hematology, Coronary Angiography, Agatston score, Coronary artery disease, Article, NO, COVID-19, Coronary artery disease, Atherosclerosis, Agatston score, Coronary artery calcifications, Calcium score, In-hospital mortality, 03 medical and health sciences, 0302 clinical medicine, Interquartile range, Risk Factors, Internal medicine, Coronary artery calcifications, Clinical endpoint, Medicine, Humans, Myocardial infarction, cardiovascular diseases, Coronary atherosclerosis, Subclinical infection, Aged, Retrospective Studies, business.industry, SARS-CoV-2, Hazard ratio, COVID-19, Middle Aged, medicine.disease, Atherosclerosis, Coronary Vessels, Calcium score, In-hospital mortality, 030104 developmental biology, Atherosclerosi, Cardiology, Calcium, atherosclerosis, Cardiology and Cardiovascular Medicine, business |
| الوصف: | Background and aims The potential impact of coronary atherosclerosis, as detected by coronary artery calcium, on clinical outcomes in COVID-19 patients remains unsettled. We aimed to evaluate the prognostic impact of clinical and subclinical coronary artery disease (CAD), as assessed by coronary artery calcium score (CAC), in a large, unselected population of hospitalized COVID-19 patients undergoing non-gated chest computed tomography (CT) for clinical practice. Methods SARS-CoV 2 positive patients from the multicenter (16 Italian hospitals), retrospective observational SCORE COVID-19 (calcium score for COVID-19 Risk Evaluation) registry were stratified in three groups: (a) “clinical CAD” (prior revascularization history), (b) “subclinical CAD” (CAC >0), (c) “No CAD” (CAC=0). Primary endpoint was in-hospital mortality and the secondary endpoint was a composite of myocardial infarction and cerebrovascular accident (MI/CVA). Results Amongst 1625 patients (male 67.2%, median age 69 [interquartile range 58-77] years), 31%, 57.8% and 11.1% had no, subclinical and clinical CAD, respectively. Increasing rates of in-hospital mortality (11.3% vs. 27.3% vs. 39.8%, p400, respectively, p Graphical abstract Image 1 |
| اللغة: | English |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f7601280de5919c8a12dd71c125bfd3Test http://hdl.handle.net/10281/314744Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....8f7601280de5919c8a12dd71c125bfd3 |
| قاعدة البيانات: | OpenAIRE |
| الوصف غير متاح. |