Lymph Node Metastasis and Extrathyroidal Extension in Papillary Thyroid Microcarcinoma in Cyprus: Suspicious Subcentimeter Nodules Should Undergo FNA When Multifocality is Suspected
| العنوان: | Lymph Node Metastasis and Extrathyroidal Extension in Papillary Thyroid Microcarcinoma in Cyprus: Suspicious Subcentimeter Nodules Should Undergo FNA When Multifocality is Suspected |
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| المؤلفون: | Panayiotis A. Economides, Christos Papaioannou, Aliki Economides, Vasilis Constantinides, Demetris Lamnisos, Katerina Kyriacou, Savvas Frangos, Theodoros Lyssiotis |
| المصدر: | Journal of Thyroid Research Journal of Thyroid Research, Vol 2020 (2020) |
| بيانات النشر: | Hindawi, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | medicine.medical_specialty, Article Subject, business.industry, Endocrinology, Diabetes and Metabolism, medicine.medical_treatment, Thyroid, Thyroidectomy, Papillary Thyroid Microcarcinoma, 030209 endocrinology & metabolism, Retrospective cohort study, Lymph node metastasis, RC648-665, medicine.disease, Lateral neck, Diseases of the endocrine glands. Clinical endocrinology, Metastasis, 03 medical and health sciences, 0302 clinical medicine, medicine.anatomical_structure, 030220 oncology & carcinogenesis, medicine, Radiology, business, Lymph node, Research Article |
| الوصف: | Objective. To determine the prevalence of lymph node (LN) metastasis and extrathyroidal extension (ETE) in patients with papillary thyroid microcarcinoma (PTMC) in Cyprus and to evaluate the role of preoperative ultrasound (U/S) examination. Methods. A retrospective study of 102 patients who underwent thyroidectomy for PTMC in a 2-year period. Preoperatively, all patients had a thyroid and neck U/S examination with LN mapping. Tumor size according to the largest diameter, number of foci, LN metastasis, and ETE data was collected from the histopathological report and was compared to the preoperative U/S reports. Results. LN metastasis was present in 23.5% of patients. 15.7% had central, 3.9% had lateral, and 3.9% had both central and lateral LN metastasis. ETE was present in 27.5% of patients. 21.6% had multifocal disease, and in this group, 40.9% had LN metastasis and 36.4% had ETE. Multifocality (p=0.03), size of tumor (p=0.05), and ETE (p≤0.001) were significantly associated with LN metastasis. The prevalence of LN metastasis in multifocal PTMC ≤5 mm was the same with multifocal PTMC >5 mm. The preoperative U/S sensitivity for the suspicious lateral neck and central LN was 100%, and the specificity was 100%. The preoperative U/S sensitivity for nodules suspicious for ETE was 53.6%, and the specificity was 100%. Conclusion. The presence of LN metastasis and ETE in our PTMC patients in Cyprus is frequent. Neck U/S mapping is a highly reliable and accurate tool in identifying metastatic nodes. LN metastasis is associated with ETE and multifocality. Suspicious subcentimeter nodules should undergo FNA irrespective of size when multifocality is suspected. |
| وصف الملف: | text/xhtml |
| اللغة: | English |
| تدمد: | 2042-0072 2090-8067 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f72bf5ad19068e8e099f264cc6ab0c1Test http://europepmc.org/articles/PMC7128046Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....8f72bf5ad19068e8e099f264cc6ab0c1 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20420072 20908067 |
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