Toll-Interacting Protein in Pulmonary Diseases. Abiding by the Goldilocks Principle
| العنوان: | Toll-Interacting Protein in Pulmonary Diseases. Abiding by the Goldilocks Principle |
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| المؤلفون: | Yingze Zhang, Alyssa D. Gregory, Xiaoyun Li, Daniel J. Kass, Gillian C Goobie |
| المصدر: | American Journal of Respiratory Cell and Molecular Biology |
| بيانات النشر: | American Thoracic Society, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Graft Rejection, 0301 basic medicine, Pulmonary and Respiratory Medicine, TOLLIP Protein, Clinical Biochemistry, Cell, communicable diseases, Biology, Respirovirus Infections, Mice, 03 medical and health sciences, 0302 clinical medicine, medicine, Animals, Humans, Tuberculosis, Pulmonary, Molecular Biology, lung diseases, Translational Reviews, TOLLIP, Intracellular Signaling Peptides and Proteins, genetic research, biomarkers, food and beverages, Signal transducing adaptor protein, Cell Biology, Asthma, Idiopathic Pulmonary Fibrosis, Immunity, Innate, Cell biology, Disease Models, Animal, MicroRNAs, 030104 developmental biology, medicine.anatomical_structure, Gene Expression Regulation, 030228 respiratory system, Goldilocks principle, Cytokines, TOLLIP protein, Toll-Interacting Protein, Legionnaires' Disease, human activities, Intracellular, Lung Transplantation, Signal Transduction |
| الوصف: | TOLLIP (Toll-interacting protein) is an intracellular adaptor protein with diverse actions throughout the body. In a context- and cell type–specific manner, TOLLIP can function as an inhibitor of inflammation and endoplasmic-reticulum stress, an activator of autophagy, or a critical regulator of intracellular vacuole trafficking. The distinct functions of this protein have been linked to innate immune responses and lung epithelial-cell apoptosis. TOLLIP genetic variants have been associated with a variety of chronic lung diseases, including idiopathic pulmonary fibrosis, asthma, and primary graft dysfunction after lung transplantation, and with infections, such as tuberculosis, Legionella pneumonia, and respiratory viruses. TOLLIP exists in a delicate homeostatic balance, with both positive and negative effects on the trajectory of pulmonary diseases. This translational review summarizes the genetic and molecular associations that link TOLLIP to the development and progression of noninfectious and infectious pulmonary diseases. We highlight current limitations of in vitro and in vivo models in assessing the role of TOLLIP in these conditions, and we describe future approaches that will enable a more nuanced exploration of the role of TOLLIP in pulmonary conditions. There has been a surge in recent research evaluating the role of this protein in human diseases, but critical mechanistic pathways require further exploration. By understanding its biologic functions in disease-specific contexts, we will be able to determine whether TOLLIP can be therapeutically modulated to treat pulmonary diseases. |
| تدمد: | 1535-4989 1044-1549 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f3c7f8b2894c0d2aab1fd910e80eef4Test https://doi.org/10.1165/rcmb.2020-0470trTest |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....8f3c7f8b2894c0d2aab1fd910e80eef4 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15354989 10441549 |
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