Comparison of the Responses to Hypoxia, Ischaemia and Ischaemic Preconditioning in Wild Marmot and Laboratory Rabbit Hearts
| العنوان: | Comparison of the Responses to Hypoxia, Ischaemia and Ischaemic Preconditioning in Wild Marmot and Laboratory Rabbit Hearts |
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| المؤلفون: | Wade Mendenhall, Tom McKean |
| المصدر: | Journal of Experimental Biology. 199:693-697 |
| بيانات النشر: | The Company of Biologists, 1996. |
| سنة النشر: | 1996 |
| مصطلحات موضوعية: | medicine.medical_specialty, Physiology, Myocardial Ischemia, Ischemia, Myocardial Reperfusion Injury, Marmot, In Vitro Techniques, Aquatic Science, Biology, chemistry.chemical_compound, Species Specificity, Lactate dehydrogenase, Internal medicine, Heart rate, medicine, Animals, Hypoxia, Molecular Biology, Cell damage, Ecology, Evolution, Behavior and Systematics, Heart, Anatomy, medicine.disease, biology.organism_classification, Adaptation, Physiological, Cardiovascular physiology, Perfusion, chemistry, Marmota, Insect Science, Ventricular pressure, Cardiology, Animal Science and Zoology, Rabbits |
| الوصف: | Marmots (Marmota flaviventris) are burrowing mammals that may be subjected to low levels of oxygen and high levels of carbon dioxide in their underground environment. Since marmots successfully deal with this physiological challenge, we hypothesized that the isolated perfused marmot heart would be damaged less and recover better from a bout of induced hypoxia or ischaemia than would the heart of a comparison animal, the New Zealand laboratory rabbit (Oryctolagus cuniculus). Isolated marmot and rabbit hearts were made hypoxic by a 30 min perfusion with an oxygen-deficient buffer. The hearts were then perfused with an oxygen-replete buffer and measurements of heart rate, left ventricular pressure and lactate dehydrogenase (LDH) release (an indicator of cell damage) were made over 5 or 10 min intervals for 30 min of hypoxia and 30 min of recovery. There were no species differences in the responses, except that the heart rate in marmots was about 50 % of the rate in rabbits during the hypoxia part of the experiment. There was no evidence that the marmot hearts were damaged less or recovered better from hypoxia and reoxgenation than the rabbit hearts. Marmot and rabbit hearts were also subjected to 30 min of total ischaemia; measurements of heart rate, left ventricular pressure and LDH release were obtained during 30 min of reperfusion and compared with the pre-ischaemia values for these variables. There were no significant species differences. When the 30 min ischaemic period was preceded by a 5 min period of ischaemia and a 10 min reperfusion period (preconditioning), the rabbit hearts were protected by this brief ischaemic insult and recovered better than the hearts that had not been subjected to the preconditioning ischaemia. This was not true in the marmot hearts, however, as the preconditioning ischaemia did not promote a greater recovery over that in its absence. When preconditioned marmots hearts were compared with preconditioned rabbit hearts, there were no statistical differences in the responses. The hypothesis that marmot hearts would be damaged less and recover better from hypoxia and ischaemia was not supported by the experimental data. |
| تدمد: | 1477-9145 0022-0949 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f29a0b778cc38de9427e6fe21703fdfTest https://doi.org/10.1242/jeb.199.3.693Test |
| حقوق: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....8f29a0b778cc38de9427e6fe21703fdf |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14779145 00220949 |
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