A Kinetic-Based Model of Radiation-Induced Intercellular Signalling
| العنوان: | A Kinetic-Based Model of Radiation-Induced Intercellular Signalling |
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| المؤلفون: | Joe M. O'Sullivan, Giuseppe Schettino, Kevin M. Prise, Alan R. Hounsell, Karl T. Butterworth, Colman Trainor, Stephen J. McMahon, Conor K. McGarry |
| المصدر: | PLoS ONE McMahon, S J, Butterworth, K T, Trainor, C, McGarry, C K, O'Sullivan, J M, Schettino, G, Hounsell, A R & Prise, K M 2013, ' A Kinetic-Based Model of Radiation-Induced Intercellular Signalling ', PloS one, vol. 8, no. 1, e54526 . https://doi.org/10.1371/journal.pone.0054526Test PLoS ONE, Vol 8, Iss 1, p e54526 (2013) |
| بيانات النشر: | Public Library of Science, 2013. |
| سنة النشر: | 2013 |
| مصطلحات موضوعية: | Cancer Treatment, lcsh:Medicine, Genotoxic Stress, Cell Communication, DOUBLE-STRAND BREAKS, Toxicology, BYSTANDER, Molecular Cell Biology, Bystander effect, Signaling in Cellular Processes, lcsh:Science, Multidisciplinary, Radiation, INDUCTION, Physics, Cell biology, Signalling, Oncology, SURVIVAL, Medicine, Signal transduction, Intracellular, Research Article, Signal Transduction, Cell signaling, TISSUES, DNA damage, Cell Survival, X-RAYS, Radiation Biophysics, Biophysics, Radiation Therapy, Biology, In vivo, Humans, Radiotherapy, lcsh:R, Computational Biology, Radiobiology, Bystander Effect, Models, Theoretical, FIELDS, IRRADIATION, CELLULAR-RESPONSE, Radiation Effects, Kinetics, CELLS, lcsh:Q, DNA Damage |
| الوصف: | It is now widely accepted that intercellular communication can cause significant variations in cellular responses to genotoxic stress. The radiation-induced bystander effect is a prime example of this effect, where cells shielded from radiation exposure see a significant reduction in survival when cultured with irradiated cells. However, there is a lack of robust, quantitative models of this effect which are widely applicable. In this work, we present a novel mathematical model of radiation-induced intercellular signalling which incorporates signal production and response kinetics together with the effects of direct irradiation, and test it against published data sets, including modulated field exposures. This model suggests that these so-called "bystander" effects play a significant role in determining cellular survival, even in directly irradiated populations, meaning that the inclusion of intercellular communication may be essential to produce robust models of radio-biological outcomes in clinically relevant in vivo situations. |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 1932-6203 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f1e688e9f9d2b5f0791c6e5ad05491fTest http://europepmc.org/articles/PMC3551852Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....8f1e688e9f9d2b5f0791c6e5ad05491f |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 19326203 |
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