A genome-wide association study of breast cancer in women of African ancestry
| العنوان: | A genome-wide association study of breast cancer in women of African ancestry |
|---|---|
| المؤلفون: | Carolyn M. Hutter, Olufunmilayo I. Olopade, Clement Adebamowo, Jirong Long, Michael S. Simon, Christine B. Ambrosone, Xin Sheng, Sandra L. Deming, Esther M. John, Elisa V. Bandera, Stephen J. Chanock, Laurence N. Kolonel, Gary K. Chen, Brian E. Henderson, Edward A. Ruiz-Narváez, Suhn K. Rhie, William J. Blot, Stefan Ambs, Robert C. Millikan, David Van Den Berg, Loreall Pooler, Wei Zheng, Lisa B. Signorello, Timothy R. Rebbeck, Angela DeMichele, Regina G. Ziegler, Yonglan Zheng, Sue A. Ingles, Leslie Bernstein, Sarah J. Nyante, Alicia Young, Qiuyin Cai, Daniel O. Stram, Jorge L. Rodriguez-Gil, Anselm Hennis, Nancy J. Cox, Suh Yuh Wu, Katherine L. Nathanson, Michael F. Press, Fang Chen, M. Cristina Leske, Susan M. Domchek, Guoliang Li, Ulrike Peters, Christopher A. Haiman, Barbara Nemesure, Loic Le Marchand, Peggy Wan, Temidayo O. Ogundiran, Jennifer J. Hu, Dezheng Huo, Julie R. Palmer, Charles Kooperberg |
| المصدر: | Human Genetics. 132:39-48 |
| بيانات النشر: | Springer Science and Business Media LLC, 2012. |
| سنة النشر: | 2012 |
| مصطلحات موضوعية: | Adult, Black People, Breast Neoplasms, Genome-wide association study, Single-nucleotide polymorphism, Biology, Polymorphism, Single Nucleotide, Article, Cohort Studies, Young Adult, Breast cancer, Risk Factors, Polymorphism (computer science), Genetics, medicine, Humans, Genetic Predisposition to Disease, Young adult, Genotyping, Genetics (clinical), Aged, Genetic association, Aged, 80 and over, Case-control study, Middle Aged, medicine.disease, Black or African American, Case-Control Studies, Female, Genome-Wide Association Study |
| الوصف: | Genome-wide association studies (GWAS) in diverse populations are needed to reveal variants that are more common and/or limited to defined populations. We conducted a GWAS of breast cancer in women of African ancestry, with genotyping of1,000,000 SNPs in 3,153 African American cases and 2,831 controls, and replication testing of the top 66 associations in an additional 3,607 breast cancer cases and 11,330 controls of African ancestry. Two of the 66 SNPs replicated (p0.05) in stage 2, which reached statistical significance levels of 10(-6) and 10(-5) in the stage 1 and 2 combined analysis (rs4322600 at chromosome 14q31: OR = 1.18, p = 4.3 × 10(-6); rs10510333 at chromosome 3p26: OR = 1.15, p = 1.5 × 10(-5)). These suggestive risk loci have not been identified in previous GWAS in other populations and will need to be examined in additional samples. Identification of novel risk variants for breast cancer in women of African ancestry will demand testing of a substantially larger set of markers from stage 1 in a larger replication sample. |
| تدمد: | 1432-1203 0340-6717 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8eeb08524b80f322d3e2942a4dbd671bTest https://doi.org/10.1007/s00439-012-1214-yTest |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....8eeb08524b80f322d3e2942a4dbd671b |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14321203 03406717 |
|---|