Characterizing the Effects of Diabetes and Obesity on Insulin and Leptin Levels amongst Pregnant Women
| العنوان: | Characterizing the Effects of Diabetes and Obesity on Insulin and Leptin Levels amongst Pregnant Women |
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| المؤلفون: | Janice J. Hwang, Christina S. Han, Renata B. DeAguiar, Lisa Parikh, Denis Snegovskikh, Andrea Johnson |
| المصدر: | American Journal of Perinatology. 37:1094-1101 |
| بيانات النشر: | Georg Thieme Verlag KG, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Adult, Blood Glucose, Leptin, medicine.medical_specialty, medicine.medical_treatment, Overweight, Body Mass Index, 03 medical and health sciences, 0302 clinical medicine, Pregnancy, Internal medicine, Diabetes mellitus, Birth Weight, Humans, Insulin, Medicine, Obesity, 030212 general & internal medicine, Glycated Hemoglobin, 030219 obstetrics & reproductive medicine, business.industry, Infant, Newborn, Obstetrics and Gynecology, Type 2 Diabetes Mellitus, Fetal Blood, medicine.disease, Pregnancy Complications, Diabetes, Gestational, Endocrinology, Cord blood, Pediatrics, Perinatology and Child Health, Female, medicine.symptom, business, Body mass index |
| الوصف: | Objective In this study, we assess the impact of obesity and diabetes on maternal brain and periphery, as well as fetal exposure to insulin and leptin, and two hormones that play an important role in regulating energy homeostasis. Study Design Fasting maternal plasma, fetal cord vein and artery plasma, and maternal cerebrospinal fluid (CSF) were collected in 37 women (12 lean, nondiabetic [prepregnancy body mass index (BMI): 22.9 ± 1.7 kg/m2]; 12 overweight/obese nondiabetic [BMI: 37.8 ± 7.3 kg/m2]; 13 gestational/type 2 diabetes mellitus [BMI: 29.8 ± 7.3 kg/m2]) with uncomplicated singleton pregnancies undergoing elective Cesarean delivery. HbA1C, insulin, glucose, and leptin levels were measured. Results Compared with lean mothers, mothers with obesity and diabetes mellitus (DM) had significantly lower CSF-to-plasma ratios of insulin. Moreover, mothers with obesity and DM had significantly lower cord arterial and cord venous to maternal plasma ratios of insulin, but not leptin, compared with lean mothers. There were no differences in CSF and cord blood insulin and leptin levels between obese and DM mothers. Conclusion Compared with lean individuals, mothers with obesity and DM have relative deficiencies in insulin exposure. The patterns observed in mothers with obesity and diabetes were similar highlighting the importance of the maternal metabolic environment in obesity and suggesting obese patients warrant further clinical focus. |
| تدمد: | 1098-8785 0735-1631 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e9a165ef0bb3cdd627bf3ab889c91ceTest https://doi.org/10.1055/s-0040-1702988Test |
| رقم الانضمام: | edsair.doi.dedup.....8e9a165ef0bb3cdd627bf3ab889c91ce |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 10988785 07351631 |
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