Benefit of diverse surgical approach on short-term outcomes of MEN1-related hyperparathyroidism
| العنوان: | Benefit of diverse surgical approach on short-term outcomes of MEN1-related hyperparathyroidism |
|---|---|
| المؤلفون: | Woong Youn Chung, Sun Hyung Choi, Jong Ju Jeong, Namki Hong, Jin Kyong Kim, Soon Min Choi, Yumie Rhee, Cho Rok Lee, Seung-Hyun Lee, Jandee Lee, Sang-Wook Kang, Kee-Hyun Nam, Hye Ryeon Choi |
| المصدر: | Scientific Reports Scientific Reports, Vol 10, Iss 1, Pp 1-7 (2020) |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Parathyroidectomy, Adult, Male, medicine.medical_specialty, endocrine system diseases, medicine.medical_treatment, lcsh:Medicine, 030209 endocrinology & metabolism, Article, Subtotal Parathyroidectomy, 03 medical and health sciences, 0302 clinical medicine, Postoperative Complications, Endocrinology, Forearm, medicine, Multiple Endocrine Neoplasia Type 1, Humans, MEN1, Multiple endocrine neoplasia, lcsh:Science, Aged, Aged, 80 and over, Hyperparathyroidism, Multidisciplinary, business.industry, lcsh:R, Endocrine system and metabolic diseases, Middle Aged, medicine.disease, Surgery, medicine.anatomical_structure, Hypoparathyroidism, 030220 oncology & carcinogenesis, lcsh:Q, Female, business, Primary hyperparathyroidism |
| الوصف: | Surgical excision is the preferred treatment for multiple endocrine neoplasia type 1 (MEN1)-related primary hyperparathyroidism (PHPT), although controversy regarding the surgical strategy exists. We retrospectively investigated the short-term outcomes of PHPT by various surgical extents. Thirty-three patients who underwent parathyroidectomy due to MEN1-related PHPT at Yonsei Severance Hospital between 2005 and 2018 were included (age [mean ± SD], 43.4 ± 14.1 [range, 23–81] years). Total parathyroidectomy with auto-transplantation to the forearm (TPX) was the most common surgical method (17/33), followed by less-than-subtotal parathyroidectomy (LPX; 12/33) and subtotal parathyroidectomy (SPX; 4/33). There was no postoperative persistent hyperparathyroidism. Recurrence was high in the LPX group without significance (1 in TPX, 2 in SPX, and 3 in LPX, p = 0.076). Permanent and transient hypoparathyroidism were more common in TPX (n = 6/17, 35.3%, p = 0.031; n = 4/17, 23.5%, p = 0.154, respectively). Parathyroid venous sampling (PVS) was introduced in 2013 for preoperative localisation of hyperparathyroidism at our hospital; nine among 19 patients operated on after 2013 underwent pre-parathyroidectomy PVS, with various surgical extents, and no permanent hypoparathyroidism (p = 0.033) or post-LPX recurrence was observed. Although TPX with auto-transplantation is the standard surgery for MEN1-related PHPT, surgical extent individualisation is necessary, given the postoperative hypoparathyroidism rate of TPX and feasibility of PVS. |
| تدمد: | 2045-2322 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8de4ff560435678b0eabd40f4d13ed37Test https://pubmed.ncbi.nlm.nih.gov/32606444Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....8de4ff560435678b0eabd40f4d13ed37 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20452322 |
|---|