Concurrent analysis of human equilibrative nucleoside transporter 1 and ribonucleotide reductase subunit 1 expression increases predictive value for prognosis in cholangiocarcinoma patients treated with adjuvant gemcitabine-based chemotherapy
| العنوان: | Concurrent analysis of human equilibrative nucleoside transporter 1 and ribonucleotide reductase subunit 1 expression increases predictive value for prognosis in cholangiocarcinoma patients treated with adjuvant gemcitabine-based chemotherapy |
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| المؤلفون: | Naru Kondo, Yoshiaki Murakami, Taijiro Sueda, Kenichiro Uemura, Takeshi Sudo, Hayato Sasaki, Yasushi Hashimoto |
| المصدر: | British Journal of Cancer |
| بيانات النشر: | Springer Science and Business Media LLC, 2014. |
| سنة النشر: | 2014 |
| مصطلحات موضوعية: | Male, Oncology, Cancer Research, Pathology, medicine.medical_treatment, Kaplan-Meier Estimate, Equilibrative nucleoside transporter 1, Deoxycytidine, Cholangiocarcinoma, chemistry.chemical_compound, Ribonucleotide Reductase Subunit, Aged, 80 and over, biology, gemcitabine, Middle Aged, Prognosis, adjuvant chemotherapy, Ribonucleotide reductase, Chemotherapy, Adjuvant, RRM1, Female, Adjuvant, medicine.drug, Adult, Antimetabolites, Antineoplastic, medicine.medical_specialty, Ribonucleoside Diphosphate Reductase, hENT1, Equilibrative Nucleoside Transporter 1, Internal medicine, Biomarkers, Tumor, medicine, Humans, Aged, Proportional Hazards Models, Chemotherapy, business.industry, Proportional hazards model, Tumor Suppressor Proteins, Gemcitabine, stomatognathic diseases, Bile Ducts, Intrahepatic, Cross-Sectional Studies, Bile Duct Neoplasms, chemistry, Multivariate Analysis, Clinical Study, biology.protein, business |
| الوصف: | Background: The aim of this study was to investigate the predictive and prognostic values of intratumoural human equilibrative nucleoside transporter 1 (hENT1) and ribonucleotide reductase subunit 1 (RRM1) expression in advanced cholangiocarcinoma patients treated with adjuvant gemcitabine-based chemotherapy (AGC). Methods: Intratumoural hENT1 and RRM1 expression levels were investigated immunohistochemically in 127 patients with advanced cholangiocarcinoma who underwent surgical resection (68 with AGC and 59 without AGC). The impacts of hENT1 and RRM1 expression on survival were evaluated. Results: High intratumoural hENT1 and RRM1 expression levels were observed in 86 (68%) and 67 (53%) patients, respectively. In a multivariate analysis of 68 patients who received AGC, high hENT1 (P=0.044) and low RRM1 expression (P=0.009) were independently associated with prolonged disease-free survival (DFS), whereas low RRM1 expression (P=0.024) was independently associated with prolonged overall survival (OS). Moreover, concurrent high hENT1 and low RRM1 expression was a powerful independent predictor of prolonged DFS (P |
| تدمد: | 1532-1827 0007-0920 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8db665096813c0d469b0e7f2aacc5ebcTest https://doi.org/10.1038/bjc.2014.399Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....8db665096813c0d469b0e7f2aacc5ebc |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15321827 00070920 |
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