التفاصيل البيبلوغرافية
العنوان:
Myeloid derived suppressor cells-An overview of combat strategies to increase immunotherapy efficacy
المؤلفون:
Toos Daemen , Joyce M Lubbers , Hans W. Nijman , Oana Draghiciu
المصدر:
Oncoimmunology
سنة النشر:
2014
مصطلحات موضوعية:
CD62L, L-selectin , TUMOR-BEARING MICE , MDSCs, myeloid-derived suppressor cells , STAT3, signal transducer and activator of transcription 3 , medicine.medical_treatment , ARG1, arginase-1 , ATRA, all-trans retinoic acid , PDE-5, phosphodiesterase type 5 , Review , IMCs, immature myeloid cells , HNSCC, head and neck squamous cell carcinoma , law.invention , APCs, antigen presenting cells , CARCINOMA PATIENTS , iNOS2, inducible nitric oxid synthase 2 , law , GM-CSF/CSF2, granulocyte monocyte colony stimulating factor , ANTITUMOR IMMUNITY , GSH, glutathione , TGFβ, transforming growth factor β , Immunology and Allergy , Cytotoxic T cell , JAK2, Janus kinase 2 , IN-VIVO , TCR, T cell receptor , gemcitabine , IL-1β, interleukin 1 β , NSAID, nonsteroidal anti-inflammatory drugs , c-kit, Mast/stem cell growth factor receptor , all-trans retinoic acid , TNFα, tumor necrosis factor α , IL-6, interleukin 6 , mRCC, metastatic renal cell carcinoma , CCL2, chemokine (C-C motif) ligand 2 , Oncology , VEGFR, vascular endothelial growth factor receptor , Tregs, regulatory T cells , CDDO-Me, bardoxolone methyl , ESTABLISHED TUMORS , DCs, dendritic cells , WITHANIA-SOMNIFERA , medicine.drug , MMPs, metalloproteinases (e.g., MMP9) , CTLs, cytotoxic T lymphocytes , ERK1/2, extracellular signal-regulated kinases , FoxP3, forkhead box P3 , 5-Fluorouracil , Immunology , sunitinib therapeutic vaccination , IFNγ, interferon γ , CANCER-PATIENTS , CD8(+) T-CELLS , Biology , ODN, oligodeoxynucleotides , RNS, reactive nitrogen species , ROS, reactive oxygen species , In vivo , IL-4, interleukin 4 , TAMs, tumor-associated macrophages , medicine , PGE2, prostaglandin E2 , WA, withaferin A , GITR, anti-glucocorticoid tumor necrosis factor receptor , bisphosphonates , CXCL15, chemokine (C-X-C motif) ligand 15 , Flt3, Fms-like tyrosine kinase 3 , WRE, Withaferin somnifera , NO, nitric oxide , immune suppressive mechanisms , HLA, human leukocyte antigen , SCF, stem cell factor , IMMUNOSUPPRESSIVE ACTIVITY , HSCs, hematopoietic stem cells , Cancer , COX2, cyclooxygenase 2 , Immunotherapy , NADPH, nicotinamide adenine dinucleotide phosphate-oxidase NK cells, natural killer cells , medicine.disease , myeloid-derived suppressor cells , HPV-16, human papillomavirus 16 , ADAM17, metalloproteinase domain-containing protein 17 , Gemcitabine , Blockade , TRANS-RETINOIC ACID , NOHA, N-hydroxy-L-Arginine , NAC, N-acetyl cysteine , Myeloid-derived Suppressor Cell , Suppressor , CXCL12, chemokine (C-X-C motif) ligand 12 , 5-FU, 5-fluorouracil , HIF-1α, hypoxia inducible factor 1α , IL-10, interleukin 10 , Myd88, myeloid differentiation primary response protein 88 , ICT, 3, 5, 7-trihydroxy-4′-emthoxy-8-(3-hydroxy-3-methylbutyl)-flavone , IL-13, interleukin 13
الوصف:
Myeloid-derived suppressor cells (MDSCs) contribute to tumor-mediated immune escape and negatively correlate with overall survival of cancer patients. Nowadays, a variety of methods to target MDSCs are being investigated. Based on the intervention stage of MDSCs, namely development, expansion and activation, function and turnover, these methods can be divided into: (I) prevention or differentiation to mature cells, (II) blockade of MDSC expansion and activation, (III) inhibition of MDSC suppressive activity or (IV) depletion of intratumoral MDSCs. This review describes effective mono- or multimodal-therapies that target MDSCs for the benefit of cancer treatment.
تدمد:
2162-4011
الوصول الحر:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d066a21e4c242e158360b8a1aa115a0Test https://pubmed.ncbi.nlm.nih.gov/25949858Test
حقوق:
OPEN
رقم الانضمام:
edsair.doi.dedup.....8d066a21e4c242e158360b8a1aa115a0
قاعدة البيانات:
OpenAIRE
