Potential of natural astaxanthin in alleviating the risk of cytokine storm in COVID-19
| العنوان: | Potential of natural astaxanthin in alleviating the risk of cytokine storm in COVID-19 |
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| المؤلفون: | Tomal Dattaroy, Santanu Dasgupta, Vinod Nagle, Jayanta Talukdar, Bhaskar Bhadra |
| المصدر: | Biomedicine & Pharmacotherapy, Vol 132, Iss, Pp 110886-(2020) Biomedicine & Pharmacotherapy |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | 0301 basic medicine, ARDS, Exacerbation, MSCs, mesenchymal stem cells, MPO, myeloperoxidase, Review, ICAM-1, intercellular adhesion molecule-1, Xanthophylls, Cytokine storm, M-CSF, macrophage colony-stimulating factor, PDGF, platelet-derived growth factor, Pathogenesis, 0302 clinical medicine, Risk Factors, IkB, inhibitor nuclear factor-kappa B, GSH, glutathione, TGF, transforming growth factor, NT, nitrotyrosine, TNF, tumor necrosis factor, LDH, lactate dehydrogenase, Acute respiratory distress syndrome, IL-1ra, interleukin-1 receptor antagonist, General Medicine, VEGF, vascular endothelial growth factor, CCL-3, chemokine (C-C motif) ligand 3, 030220 oncology & carcinogenesis, COX-2, cyclooxygenase-2, CRP, C-reactive protein, LPS, lipopolysaccharide, Cytokines, Tumor necrosis factor alpha, dsRNA, double stranded ribonucleic acid, Antioxidant, GM-CSF, granulocyte-macrophage colony-stimulating factor, MIP, macrophage inflammatory protein, ALT, alanine transaminase, HCFs, human cardiac fibroblasts, HDAC4, histone deacetylase 4, RM1-950, Lung injury, Antiviral Agents, stat, 03 medical and health sciences, Immune system, Fibrinolytic Agents, SOD, superoxide dismutase, medicine, PGE2, prostaglandin E2, Animals, Humans, ComputingMethodologies_COMPUTERGRAPHICS, Pharmacology, MDA, malondialdehyde, NO, nitric oxide, business.industry, PPARs, peroxisome proliferator-activated receptors, SARS-CoV-2, Astaxanthin, COVID-19, MCP, monocyte chemoattractant protein, medicine.disease, G-CSF, granulocyte colony-stimulating factor, COVID-19 Drug Treatment, 030104 developmental biology, Immunology, FOXO3, forkhead box O3 gene, HGF, hepatocyte growth factor, MMPs, matrix metalloproteinases, HIF-1α, hypoxia inducible factor 1α, Therapeutics. Pharmacology, AST, aminotransferase, Anti-inflammatory, business, MAPK, mitogen-activated protein kinase, LFA-1, leukocyte function antigen 1 |
| الوصف: | Graphical abstract Highlights • CS triggered by excessive inflammatory response drives the pathogenesis of COVID-19. • ASX inhibits TNFα, IL1β, IL6 via regulation of NF-kB & JAK/STAT; prevents CS & ALI/ARDS. • ASX suppresses plasma CRP, iNOS, COX2, PGE2 & ICAM-1; prevents oxidative damages. • ASX inhibits NLRP3, HIF1α, activates Nrf2, Sirtuin pathways; exerts antioxidant effect. • ASX enhances immune responses, NK cell activity, T- & B- cell population. Host excessive inflammatory immune response to SARS-CoV-2 infection is thought to underpin the pathogenesis of COVID-19 associated severe pneumonitis and acute lung injury (ALI) or acute respiratory distress syndrome (ARDS). Once an immunological complication like cytokine storm occurs, anti-viral based monotherapy alone is not enough. Additional anti-inflammatory treatment is recommended. It must be noted that anti-inflammatory drugs such as JAK inhibitors, IL-6 inhibitors, TNF-α inhibitors, colchicine, etc., have been either suggested or are under trials for managing cytokine storm in COVID-19 infections. Natural astaxanthin (ASX) has a clinically proven safety profile and has antioxidant, anti-inflammatory, and immunomodulatory properties. There is evidence from preclinical studies that supports its preventive actions against ALI/ARDS. Moreover, ASX has a potent PPARs activity. Therefore, it is plausible to speculate that ASX could be considered as a potential adjunctive supplement. Here, we summarize the mounting evidence where ASX is shown to exert protective effect by regulating the expression of pro-inflammatory factors IL-1β, IL-6, IL-8 and TNF-α. We present reports where ASX is shown to prevent against oxidative damage and attenuate exacerbation of the inflammatory responses by regulating signaling pathways like NF-ĸB, NLRP3 and JAK/STAT. These evidences provide a rationale for considering natural astaxanthin as a therapeutic agent against inflammatory cytokine storm and associated risks in COVID-19 infection and this suggestion requires further validation with clinical studies. |
| تدمد: | 1950-6007 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8cd7bf3aa8d9fd5d6f23a47947a5470cTest https://pubmed.ncbi.nlm.nih.gov/33113418Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....8cd7bf3aa8d9fd5d6f23a47947a5470c |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 19506007 |
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