NAP1L1 Regulates Hepatitis C Virus Entry and Interacts with NS3
| العنوان: | NAP1L1 Regulates Hepatitis C Virus Entry and Interacts with NS3 |
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| المؤلفون: | Leiliang Zhang, Ye Li, Peiqi Yin, Liya Zhou |
| المصدر: | Virologica Sinica. 33:205-208 |
| بيانات النشر: | Elsevier BV, 2018. |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | 0301 basic medicine, Letter, NAP1L1, viruses, Hepatitis C virus, Immunology, Hepacivirus, Viral Nonstructural Proteins, medicine.disease_cause, Cell Line, 03 medical and health sciences, Retrovirus, Virology, medicine, Humans, NS3, Nucleosome Assembly Protein 1, 030102 biochemistry & molecular biology, biology, virus diseases, RNA virus, DNA virus, Virus Internalization, biology.organism_classification, digestive system diseases, 030104 developmental biology, Viral replication, Cell culture, Host-Pathogen Interactions, Hepatocytes, Molecular Medicine |
| الوصف: | NAP1L1 has been shown to function in the life cycle of several DNA virus and retrovirus. However, whether NAP1L1 regulates hepatitis C virus (HCV), a positive-stranded RNA virus, remain to be elucidated. In this study, we identified NAP1L1 as a novel binding partner for HCV NS3. Our results suggest that NAP1L1 contributes to HCV entry, but not viral replication. These findings provide mechanistic insight into the role of NAP1L1 in HCV life cycle and extend the role of NAP1L1 to RNA virus. |
| تدمد: | 1995-820X 1674-0769 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c920f3cb9dd46a6e367192356466947Test https://doi.org/10.1007/s12250-018-0006-5Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....8c920f3cb9dd46a6e367192356466947 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 1995820X 16740769 |
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