Multiple Viral Strategies of HTLV-1 for Dysregulation of Cell Growth Control
| العنوان: | Multiple Viral Strategies of HTLV-1 for Dysregulation of Cell Growth Control |
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| المؤلفون: | Mitsuaki Yoshida |
| المصدر: | Annual Review of Immunology. 19:475-496 |
| بيانات النشر: | Annual Reviews, 2001. |
| سنة النشر: | 2001 |
| مصطلحات موضوعية: | CD4-Positive T-Lymphocytes, Gene Expression Regulation, Viral, Male, Transcriptional Activation, Serum Response Factor, Cell division, viruses, Immunology, T-cell leukemia, Apoptosis, Cell Cycle Proteins, Biology, Virus Replication, Models, Biological, Retrovirus, Tropical spastic paraparesis, medicine, Humans, Leukemia-Lymphoma, Adult T-Cell, Immunology and Allergy, Cyclic AMP Response Element-Binding Protein, Transcription factor, Human T-lymphotropic virus 1, Cell growth, Genes, pX, Cell Cycle, NF-kappa B, Nuclear Proteins, Gene Products, tax, Cell cycle, Cell Transformation, Viral, biology.organism_classification, medicine.disease, Virology, DNA-Binding Proteins, Viral replication, Neoplastic Stem Cells, Trans-Activators, Cancer research, Female, I-kappa B Proteins, Tumor Suppressor Protein p53, Cell Division |
| الوصف: | The human T cell leukemia virus-1 (HTLV-1) is a retrovirus that causes adult T cell leukemia (ATL) and neurological disorder, the tropical spastic paraparesis (HAM/TSP). The pathogenesis apparently results from the pleiotropic function of Tax protein, which is a key regulator of viral replication. Tax exerts (a) trans-activation and -repression of transcription of different sets of cellular genes through binding to groups of transcription factors and coactivators, (b) dysregulation of cell cycle through binding to inhibitors of CDK4/6, and (c) inhibition of some tumor suppressor proteins. These effects on a wide variety of cellular targets seem to cooperate in promoting cell proliferation. This is an effective viral strategy to amplify its proviral genome through replication of infected cells; ultimately it results in cell transformation and leukemogenesis. |
| تدمد: | 1545-3278 0732-0582 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c5ad7f3ead18626aff2b4de87edf911Test https://doi.org/10.1146/annurev.immunol.19.1.475Test |
| رقم الانضمام: | edsair.doi.dedup.....8c5ad7f3ead18626aff2b4de87edf911 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15453278 07320582 |
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