Polymorphism 4G/5G of the plasminogen activator inhibitor 1 gene as a risk factor for the development of allergic rhinitis symptoms in patients with asthma
| العنوان: | Polymorphism 4G/5G of the plasminogen activator inhibitor 1 gene as a risk factor for the development of allergic rhinitis symptoms in patients with asthma |
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| المؤلفون: | Ivona Marunica, Jasna Bingulac-Popović, Irena Jukić, Gordana Pavliša, Marina Lampalo, Sanja Popović-Grle, Roberta Petlevski |
| المصدر: | European Archives of Oto-Rhino-Laryngology. 274:2613-2619 |
| بيانات النشر: | Springer Science and Business Media LLC, 2017. |
| سنة النشر: | 2017 |
| مصطلحات موضوعية: | Adult, Male, 0301 basic medicine, Genotype, Immunoglobulin E, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Risk Factors, Interquartile range, Plasminogen Activator Inhibitor 1, Humans, Medicine, Genetic Predisposition to Disease, Risk factor, Asthma, Polymorphism, Genetic, biology, business.industry, Age Factors, Sequence Analysis, DNA, General Medicine, medicine.disease, Rhinitis, Allergic, Eosinophils, Oxygen, Logistic Models, 030104 developmental biology, 030228 respiratory system, Otorhinolaryngology, chemistry, Plasminogen activator inhibitor-1, Immunology, biology.protein, Sputum, Female, Gene polymorphism, medicine.symptom, business, Biomarkers |
| الوصف: | Plasminogen activator inhibitor-1 (PAI-1) is a glycoprotein which has a role in tissue remodelling after inflammatory processes. The objective is to investigate the frequency of PAI-1 gene polymorphism (4G/5G) in patients with a lung ventilation dysfunction in asthma and allergic rhinitis. Genomic DNA was isolated and genotypes of polymorphism of PAI-1 4G/5G and ABO were determined using the methods of RT-PCR and PCR-SSP. Study group includes 145 adult patients diagnosed with chronic asthma, with all clinically relevant parameters and the laboratory markers of pO2, IgE and eosinophils in sputum and nasal swab. In the processing of data, appropriate statistical tests (Kolmogorov–Smirnov test, median, interquartile ranges, χ 2 and Mann–Whitney U tests) were used. Patients with symptoms of allergic rhinitis were significantly younger and had an almost four time higher levels of IgE (P = 0.001), higher pO2 (P = 0.002) and PEF (P = 0.036), compared to those who do not have these symptoms. Genotype PAI 4G/4G is significantly more common in patients with allergic rhinitis (28.1% vs. 16.1%; P = 0.017) compared to the genotype 5G/5G. Carriers of the genotype 4G/5G also have a borderline statistical significance. There were no statistically significant difference in the incidence of allergic rhinitis in the carriers of any ABO genotypes. The frequency of PAI genotype 4G/4G is significantly more common in patients with allergic rhinitis. The results suggest that the carriers of at least one 4G allele are at a higher risk for developing symptoms of allergic rhinitis in asthma. |
| تدمد: | 1434-4726 0937-4477 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c204be6c83f56378b9af51d50b90cd0Test https://doi.org/10.1007/s00405-017-4502-2Test |
| حقوق: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....8c204be6c83f56378b9af51d50b90cd0 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14344726 09374477 |
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