A coordinated control strategy for insulin and glucagon delivery in type 1 diabetes
| العنوان: | A coordinated control strategy for insulin and glucagon delivery in type 1 diabetes |
|---|---|
| المؤلفون: | Pau Herrero, Jorge Bondia, Pantelis Georgiou, Nick Oliver |
| المساهمون: | Wellcome Trust, Engineering & Physical Science Research Council (EPSRC) |
| المصدر: | RiuNet. Repositorio Institucional de la Universitat Politécnica de Valéncia instname |
| بيانات النشر: | Taylor & Francis, 2017. |
| سنة النشر: | 2017 |
| مصطلحات موضوعية: | Blood Glucose, Technology, medicine.medical_treatment, GLUCOSE, Engineering, 0302 clinical medicine, Drug Delivery Systems, 0903 Biomedical Engineering, Insulin, 030212 general & internal medicine, Child, Diabetes, General Medicine, INGENIERIA DE SISTEMAS Y AUTOMATICA, 3. Good health, Computer Science Applications, Closed-loop control, SECRETION, Computer Science, Interdisciplinary Applications, Adult, Pancreas, Artificial, medicine.medical_specialty, Adolescent, Biomedical Engineering, 1105 Dentistry, 030209 endocrinology & metabolism, Bioengineering, Artificial pancreas, Glucagon, Article, 03 medical and health sciences, Paracrine signalling, Internal medicine, Diabetes mellitus, Glucose control, medicine, Endocrine system, Humans, Computer Simulation, Engineering, Biomedical, Type 1 diabetes, Science & Technology, business.industry, Bihormonal control, medicine.disease, MODEL, Human-Computer Interaction, Endocrinology, Diabetes Mellitus, Type 1, Computer Science, Insulin delivery, business, Hormone |
| الوصف: | [EN] Type 1 diabetes is an autoimmune condition characterised by a pancreatic insulin secretion deficit, resulting in high blood glucose concentrations, which can lead to micro- and macrovascular complications. Type 1 diabetes also leads to impaired glucagon production by the pancreatic -cells, which acts as a counter-regulatory hormone to insulin. A closed-loop system for automatic insulin and glucagon delivery, also referred to as an artificial pancreas, has the potential to reduce the self-management burden of type 1 diabetes and reduce the risk of hypo- and hyperglycemia. To date, bihormonal closed-loop systems for glucagon and insulin delivery have been based on two independent controllers. However, in physiology, the secretion of insulin and glucagon in the body is closely interconnected by paracrine and endocrine associations. In this work, we present a novel biologically-inspired glucose control strategy that accounts for such coordination. An in silico study using an FDA-accepted type 1 simulator was performed to evaluate the proposed coordinated control strategy compared to its non-coordinated counterpart, as well as an insulin-only version of the controller. The proposed coordinated strategy achieves a reduction of hyperglycemia without increasing hypoglycemia, when compared to its non-coordinated counterpart. This work was supported by the Wellcome Trust; the Spanish Ministry of Economy and Competitiveness (MINECO) [grant number DPI2016-78831-C2-1-R]; the EU through FEDER funds. |
| وصف الملف: | application/pdf |
| اللغة: | English |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b077371b35b2ac963c5ade78c6cfd4eTest https://doi.org/10.1080/10255842.2017.1378352Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....8b077371b35b2ac963c5ade78c6cfd4e |
| قاعدة البيانات: | OpenAIRE |
| الوصف غير متاح. |